Complexation of Chol‐DsiRNA in place of Chol‐siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)‐PEG(5K) in primary murine syngeneic breast tumors after i.v. administration
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DOI: 10.1016/j.ijpharm.2018.03.045
Abstract: &NA; RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v. administration. We previously found that complexation with PLL(30)‐PEG(5K) greatly increases the potency of 3′‐cholesterol‐modified… read more here.
Keywords: suppression; chol dsirna; chol sirna; pll peg ... See more keywords