Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation.
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DOI: 10.1002/adhm.202300913
Abstract: Chemotherapy-induced adaptive resistance is a significant factor that contributes to low therapeutic efficacy in tumor cells. The unfolded protein response (UPR) is a key mechanism in the development of drug resistance and serves as a… read more here.
Keywords: unfolded protein; cholangiocarcinoma; tmx2; increases sensitivity ... See more keywords
Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.
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DOI: 10.1002/adma.201604253
Abstract: A 2D peptidosheet unravels CD47 as a potential biomarker to image hepatocarcinoma and cholangiocarcinoma cells and tissues. Supramolecular assembly between water-soluble 2D MoS2 and a peptide probe produces the 2D peptidosheet suited for the profiling… read more here.
Keywords: unravels cd47; cholangiocarcinoma tissues; cholangiocarcinoma; cd47 potential ... See more keywords
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular‐cholangiocarcinoma after resection
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DOI: 10.1002/cam4.2495
Abstract: Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients… read more here.
Keywords: combined hepatocellular; hepatocellular cholangiocarcinoma; intrahepatic cholangiocarcinoma; cholangiocarcinoma ... See more keywords
Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
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DOI: 10.1002/cam4.2719
Abstract: Cholangiocarcinoma is a malignant tumor originating from bile duct epithelium. Currently, the treatment strategy is very limited and the prognosis is poor. Recent studies reported celastrol exhibits antigrowth and antimetastasis properties in many tumors. Our… read more here.
Keywords: proliferation invasion; celastrol inhibition; cholangiocarcinoma; antitumor activity ... See more keywords
Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma
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DOI: 10.1002/hep.28925
Abstract: Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tree. Because CCA is usually detected in advanced stages, patients are infrequently eligible for surgery, which is the only curative intervention. Unfortunately, there are currently… read more here.
Keywords: extracellular vesicles; cholangiocarcinoma; cca; cell ... See more keywords
Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half‐Opened
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DOI: 10.1002/hep.30069
Abstract: Cholangiocarcinoma (CCA), the most common biliary tract malignancy, represents a heterogeneous group of epithelial cancers arising from varying locations within the biliary tree. The anatomical subtypes of CCA are intrahepatic CCA (iCCA), which arises in… read more here.
Keywords: fibroblast growth; cholangiocarcinoma; cca; growth factor ... See more keywords
Dependency of Cholangiocarcinoma on Cyclin D–Dependent Kinase Activity
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DOI: 10.1002/hep.30704
Abstract: Cholangiocarcinoma (CCA) is a bile duct cancer with a very poor prognosis. Currently, there is no effective pharmacological treatment available for it. We showed that CCA ubiquitously relies on cyclin‐dependent kinases 4 and 6 (CDK4/6)… read more here.
Keywords: cyclin dependent; cdk4; cholangiocarcinoma; cca ... See more keywords
Lymphoepithelioma‐Like Carcinomas: A Rare Variant of Cholangiocarcinoma
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DOI: 10.1002/hep.31102
Abstract: Lymphoepithelioma-like carcinomas (LELCs) are malignancies that appear histologically as undifferentiated epithelial cells accompanied by lymphoid response (1). LELCs have been described in a variety of organs including the liver, can present with hepatocellular or cholangiocarcinoma… read more here.
Keywords: carcinomas rare; cholangiocarcinoma; lymphoepithelioma like; like carcinomas ... See more keywords
The Tumor Microenvironment in Cholangiocarcinoma Progression
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DOI: 10.1002/hep.31410
Abstract: Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree. A typical hallmark of CCA is that cancer cells are embedded into a dense stroma containing fibrogenic cells, lymphatics and a variety of… read more here.
Keywords: cholangiocarcinoma; cca; progression; tumor microenvironment ... See more keywords
Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma
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DOI: 10.1002/hep.31642
Abstract: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in… read more here.
Keywords: dual targeting; methyltransferase; cholangiocarcinoma; dna methyltransferase ... See more keywords
A potential role for aspirin in the prevention and treatment of cholangiocarcinoma
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DOI: 10.1002/ijc.33323
Abstract: Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As… read more here.
Keywords: treatment; cholangiocarcinoma; aspirin; prevention treatment ... See more keywords