Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation
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DOI: 10.1002/cam4.5322
Abstract: XPO1 mediates the nuclear export of several proteins, mainly tumor suppressors. KPT‐330 (Selinexor) is a selective inhibitor of XPO1 that has demonstrated good therapeutic effects in hematologic cancers. read more here.
Keywords: cell proliferation; xpo1; cholangiocarcinoma cell; inhibition xpo1 ... See more keywords
Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling
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DOI: 10.18632/oncotarget.15005
Abstract: Cholangiocarcinoma is a rare, but highly fatal malignancy. However, the intrinsic mechanism involved in its tumorigenesis remains obscure. An urgent need remains for a promising target for cholangiocarcinoma biological therapies. Based on comparative proteomical technologies,… read more here.
Keywords: cell; apoptosis; erk akt; induction erk ... See more keywords
Targeting Src-Hic-5 Signal Cascade for Preventing Migration of Cholangiocarcinoma Cell HuCCT1
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DOI: 10.3390/biomedicines10051022
Abstract: Cholangiocarcinoma (CCA) is the second most common primary liver cancer with poor prognosis. The deregulation of a lot of oncogenic signaling molecules, such as receptor tyrosine kinases (RTKs), has been found to be associated with… read more here.
Keywords: hucct1; migration; src; cholangiocarcinoma cell ... See more keywords
Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1
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DOI: 10.4103/0366-6999.221271
Abstract: Background: Decoy receptor 3 (DcR3) is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression… read more here.
Keywords: cell line; cell; cholangiocarcinoma; dcr3 ... See more keywords