Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in immunopathology"
DOI: 10.1007/s00281-022-00909-9
Abstract: The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are three cholangiopathies with… read more here.
Keywords: cellular senescence; pbc psc; immunopathology; cholangiocyte senescence ... See more keywords
The epigenetic reader, BRD2, mediates cholangiocyte senescence via interaction with ETS1.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.03.235
Abstract: BACKGROUND & AIMS We reported that cholangiocyte senescence, regulated by the transcription factor, ETS1, is a pathogenic feature of Primary Sclerosing Cholangitis (PSC). Furthermore, Histone 3 Lysine 27 is acetylated at senescence-associated loci. The epigenetic… read more here.
Keywords: cholangiocyte senescence; bet; senescence; gene expression ... See more keywords