3β-Acetoxy cholest-5-ene crystals: Catalytic synthesis, structural elucidation, contribution of intermolecular interactions and density functional theory calculations
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DOI: 10.1016/j.molstruc.2020.128833
Abstract: Abstract In this work, we present the synthesis of 3β-acetoxy cholest-5-ene using zinc triflate Zn(OTf)2 as a catalyst. The synthesized molecule has been characterized by single crystal XRD, spectroscopic techniques and density functional theory (DFT)… read more here.
Keywords: density functional; acetoxy cholest; cholest ene; intermolecular interactions ... See more keywords
Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells
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DOI: 10.1016/j.steroids.2020.108638
Abstract: Cholest-4-ene-3,6-dione (KS) is a cholesterol oxidation product which exhibits anti-proliferative activity. However, its precise mechanism of action remains unknown. In this study, the effects of KS on AKR1C3 inhibition and anti-proliferative activities were investigated in… read more here.
Keywords: anti proliferative; cholest ene; mcf; inhibition ... See more keywords