Hepatitis E in decompensated alcoholic cirrhosis
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DOI: 10.1002/hep.28792
Abstract: cholestasis. HEPATOLOGY 2016;64:535-548. 3) Marrone J, Lehmann GL, Soria LR, Pellegrino JM, Molinas S, Marinelli RA. Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen induced cholestasis. Gene Ther 2014;21:1058-1064.… read more here.
Keywords: physiol; water; aquaporin water; marinelli ... See more keywords
Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis
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DOI: 10.1002/hep.29019
Abstract: To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis‐1 (FIC1), 18 with bile salt export pump (BSEP) disease, and… read more here.
Keywords: fic1; pediatric cholestasis; preoperatively months; bsep ... See more keywords
Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29585
Abstract: β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by… read more here.
Keywords: dual catenin; catenin; intrahepatic cholestasis; cholestasis ... See more keywords
Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis
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DOI: 10.1002/hep.30196
Abstract: Osteopenia and bone fractures are significant causes of morbidity in children with cholestatic liver disease. Dual‐energy X‐ray absorptiometry (DXA) analysis was performed in children with intrahepatic cholestatic diseases who were enrolled in the Longitudinal Study… read more here.
Keywords: liver disease; bone; cholestasis; algs ... See more keywords
Plectin Mutations in Progressive Familial Intrahepatic Cholestasis
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DOI: 10.1002/hep.30841
Abstract: Neonates and infants are susceptible to cholestatic liver diseases. At least six genes are causative for progressive familial intrahepatic cholestasis (PFIC), and more genetic defects are known to cause infant cholestasis.(1) Approximately one-third of PFIC… read more here.
Keywords: familial intrahepatic; plec; progressive familial; intrahepatic cholestasis ... See more keywords
Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling
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DOI: 10.1002/hep.32028
Abstract: Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (i)… read more here.
Keywords: mast cells; cholestasis; ductular reaction; farnesoid receptor ... See more keywords
TJP2 hepatobiliary disorders: Novel variants and clinical diversity
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DOI: 10.1002/humu.23947
Abstract: To assess the spectrum of pediatric clinical phenotypes in TJP2 disease, we reviewed records of our seven patients in whom intrahepatic cholestasis was associated with biallelic TJP2 variants (13; 12 novel) and correlated clinical manifestations… read more here.
Keywords: disorders novel; tjp2 hepatobiliary; disease; tjp2 ... See more keywords
Association of novel TMEM67 variants with mild phenotypes of high gamma‐glutamyl transpeptidase cholestasis and congenital hepatic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30788
Abstract: TMEM67 (mecklin or MKS3) locates in the transition zone of cilia. Dysfunction of TMEM67 disrupts cilia‐related signaling and leads to developmental defects of multiple organs in humans. Typical autosomal recessive TMEM67 defects cause partial overlapping… read more here.
Keywords: cholestasis; tmem67 variants; tmem67; glutamyl transpeptidase ... See more keywords
Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis.
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DOI: 10.1007/978-1-4939-9420-5_20
Abstract: Cholestasis remains a major challenge in drug-induced liver injury, and therefore warrants identification of chemical entities that may lead to cholestasis. Recent advances in cell culture methods enable 3D spheroid models to remain viable for… read more here.
Keywords: heparg liver; drug induced; drug; cholestasis ... See more keywords
Use of Biliary Organoids in Cholestasis Research.
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DOI: 10.1007/978-1-4939-9420-5_25
Abstract: Cholangiocytes play a crucial role in the pathophysiology of cholestasis. However, research on human cholangiocytes has been restricted by challenges in long-term propagation and large-scale expansion of primary biliary epithelium. The advent of organoid technology… read more here.
Keywords: biliary organoids; research; cholestasis research; use biliary ... See more keywords
In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis.
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DOI: 10.1007/978-1-4939-9420-5_26
Abstract: Transport proteins play a crucial role in drug distribution, disposition, and clearance by mediating cellular drug influx and efflux. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury, such as… read more here.
Keywords: predict drug; approaches predict; drug; silico approaches ... See more keywords