Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice ‡
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DOI: 10.1002/hep.28831
Abstract: Biliary‐committed progenitor cells (small mouse cholangiocytes; SMCCs) from small bile ducts are more resistant to hepatobiliary injury than large mouse cholangiocytes (LGCCs) from large bile ducts. The definitive endoderm marker, forkhead box A2 (FoxA2), is… read more here.
Keywords: cholestatic liver; senescence; liver; liver injury ... See more keywords
The ascending pathophysiology of cholestatic liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28965
Abstract: In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with anatomically an ascending course of the disease process. The first and… read more here.
Keywords: cholestatic liver; disease; liver; pathophysiology ... See more keywords
Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29838
Abstract: Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released by a variety of cells, including cholangiocytes. Exosome‐mediated cell‐cell communication can modulate various cellular functions… read more here.
Keywords: cholestatic liver; hepatology; cholangiocyte derived; liver injury ... See more keywords
Wnt/β‐Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30927
Abstract: The Wnt/β‐catenin signaling pathway has a well‐described role in liver pathobiology. Its suppression was recently shown to decrease bile acid (BA) synthesis, thus preventing the development of cholestatic liver injury and fibrosis after bile duct… read more here.
Keywords: catenin signaling; cholestatic liver; liver; role ... See more keywords
Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury
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DOI: 10.1002/hep.31494
Abstract: Cholestatic liver injury leads to cell death and subsequent inflammation and fibrosis. As shown for primary biliary cholangitis (PBC), the mechanisms and circuits between different cell death pathways leading to disease progression are incompletely defined.… read more here.
Keywords: liver injury; cholestatic liver; role; cell death ... See more keywords
Cholestatic Liver Diseases After Liver Transplant.
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DOI: 10.1016/j.cld.2016.12.011
Abstract: Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases (CLD) in adults. Liver transplant (LT) is desirable for those who progress to end-stage liver disease. CLD have become… read more here.
Keywords: pbc; cholestatic liver; liver diseases; liver transplant ... See more keywords
Dialogues in the assessment of neonatal cholestatic liver disease.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.12.007
Abstract: Neonatal cholestatic liver disease is rarely encountered by pathologists outside of specialized pediatric centers and navigating the long list of potential diseases can be daunting. However, the differential diagnosis can be rapidly narrowed through open… read more here.
Keywords: liver disease; cholestatic liver; neonatal cholestatic; dialogues assessment ... See more keywords
Polydatin protects against acute cholestatic liver injury in mice via the inhibition of oxidative stress and endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.02.029
Abstract: Abstract Cholestatic liver injury is a chronic disease caused by the retention of toxic hydrophobic bile salts in the liver, but lack of efficient therapy. Here, we identified that polydatin (PD), a natural precursor of… read more here.
Keywords: stress; liver injury; cholestatic liver; mice ... See more keywords
Substance-P prevents the cholestatic liver injury by regulating inflammatory responses
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DOI: 10.1016/j.peptides.2021.170494
Abstract: Substance-P (SP) is a neuropeptide that modulates immune responses and accelerates tissue repair in critical inflammatory disease. Liver fibrosis and cirrhosis are the ultimate outcomes of almost all chronic liver diseases caused by viral infection,… read more here.
Keywords: substance; cbdl; liver fibrosis; cholestatic liver ... See more keywords
Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02123
Abstract: Peroxisome proliferator-activator receptors α/δ (PPARα/δ) are considered as potential drug targets for cholestatic liver diseases (CLD) via ameliorating hepatic cholestasis, inflammation, and fibrosis. In this work, we developed a series of hydantoin derivatives as potent… read more here.
Keywords: ppar; ppar dual; liver diseases; discovery first ... See more keywords
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis
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DOI: 10.1038/s41374-021-00710-6
Abstract: Cholestasis causes ductular reaction in the liver where the reactive cholangiocytes not only proliferate but also gain a neuroendocrine-like phenotype, leading to inflammatory cell infiltration and extracellular matrix deposition and contributing to the development and… read more here.
Keywords: activation; liver; liver fibrosis; mir 200c ... See more keywords