Statins and the Prevention of Heart Disease.
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DOI: 10.1001/jamacardio.2016.4320
Abstract: How Do Statins Work? Statin medications are a class of lipid-lowering medications that inhibit a step used by the liver to synthesize cholesterol. Statins reduce the health risks related to atherosclerosis by lowering cholesterol. Atherosclerosis… read more here.
Keywords: statins prevention; cardiology; heart disease; prevention heart ... See more keywords
Statins-Almost 30 Years of Use in the United States and Still Not Quite There.
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DOI: 10.1001/jamacardio.2016.4709
Abstract: The first statin, lovastatin, was approved for commercial use in the United States almost 30 years ago on September 1, 1987. Since that time, tens of millions of individuals have been treated with statins as… read more here.
Keywords: use united; risk; cardiology; cholesterol ... See more keywords
Perspective on Trends in Statin Use.
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DOI: 10.1001/jamacardio.2016.4710
Abstract: Since their introduction in the 1990s, statins have become the most common class of prescription medications in the United States.1 Statins work by blocking the critical pathway in the synthesis of cholesterol in the liver.… read more here.
Keywords: statin use; use; cardiology; cholesterol ... See more keywords
Author Name Change.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2017.0102
Abstract: Incorrect Conversion Factor in Table and Text: In the Original Investigation titled “Drugs for Primary Prevention of Atherosclerotic Cardiovascular Disease: An Overview of Systematic Reviews,” published in the June issue of JAMA Cardiology,1 a conversion… read more here.
Keywords: author name; reduction; cardiology; cholesterol ... See more keywords
PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity.
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DOI: 10.1001/jamacardio.2017.2727
Abstract: PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity To the Editor In a study by Koren et al,1 proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors exhibited potent and persistent long-term efficacy in reducing… read more here.
Keywords: pcsk9 inhibitors; ldl cholesterol; mevalonate pathway; cholesterol ... See more keywords
Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population.
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DOI: 10.1001/jamacardio.2021.3728
Abstract: Importance The balance between the potential long-term clinical benefits and harms associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking pharmacologic CETP inhibition, is unknown. Objective To assess the relative benefits and harms associated… read more here.
Keywords: hdl cholesterol; risk; associated genetic; cholesterol ... See more keywords
Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.5271
Abstract: Importance Protein-truncating variants (PTVs) in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low-density lipoprotein (LDL) cholesterol concentrations. The association of these PTVs with coronary heart disease (CHD)… read more here.
Keywords: apob pcsk9; ldl cholesterol; cholesterol level; risk ... See more keywords
Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
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DOI: 10.1001/jamanetworkopen.2021.41898
Abstract: Importance Intense interest exists in novel ω-3 formulations with high bioavailability to reduce blood triglyceride (TG) levels. Objective To determine the phase 3 efficacy and safety of a naturally derived krill oil with eicosapentaenoic acid… read more here.
Keywords: krill oil; severe hypertriglyceridemia; mean treatment; cholesterol ... See more keywords
Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.
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DOI: 10.1002/1348-9585.12275
Abstract: OBJECTIVE The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of… read more here.
Keywords: sleep time; cholesterol; study; total sleep ... See more keywords
Cerivastatin for lowering lipids.
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DOI: 10.1002/14651858.cd012501
Abstract: BACKGROUND: Cerivastatin was the most potent statin until it was withdrawn from the market due to a number of fatalities due to rhabdomyolysis, however, the dose-related magnitude of effect of cerivastatin on blood lipids is… read more here.
Keywords: ldl cholesterol; rosuvastatin; cholesterol; cerivastatin ... See more keywords
Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes
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DOI: 10.1002/1873-3468.14375
Abstract: Lipid‐like ion‐pair amphiphile vesicles, or catanionic vesicles, have emerged as potential drug carriers. The effects of cholesterol on the properties of catanionic vesicles have yet been systematically studied. Here, we compared the effects of cholesterol… read more here.
Keywords: divergent effects; effects cholesterol; structure fluidity; catanionic vesicles ... See more keywords