Aberrant Brain Bile Acid Signaling and Cholesterol Accumulation: A New Look at Mechanisms in Hepatic Encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.04.004
Abstract: he article by McMillin et al in the current issue Tof Cellular and Molecular Gastroenterology and Hepatology documents increased cholesterol accumulation in cerebral cortical neurons of mice treated with the liver toxin azoxymethane (AOM) that… read more here.
Keywords: bile acid; gastroenterology; cholesterol accumulation; cholesterol ... See more keywords
Lupus nephritis: Cholesterol accumulation in DCs promotes autoimmunity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Nephrology"
DOI: 10.1038/nrneph.2017.72
Abstract: Cholesterol accumulation in dendritic cells (DCs) activates inflammatory signalling pathways that promote autoimmunity. This new finding from Marit Westerterp and colleagues suggests that suppression of DC cholesterol efflux pathways might have a role in the… read more here.
Keywords: dcs; cholesterol accumulation; cholesterol; abca1 abcg1 ... See more keywords
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac189
Abstract: Abstract Aims Neutrophil extracellular trap formation (NETosis) increases atherosclerotic plaque vulnerability and athero-thrombosis. However, mechanisms promoting NETosis during atherogenesis are poorly understood. We have shown that cholesterol accumulation due to myeloid cell deficiency of the… read more here.
Keywords: netosis; cholesterol accumulation; netosis atherosclerotic; atherosclerotic plaques ... See more keywords
Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells[S]
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m085886
Abstract: In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS). We examined the effect… read more here.
Keywords: insulin secretion; cholesterol accumulation; angiotensin; regulating abca1 ... See more keywords
The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression
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DOI: 10.3390/ijms24076426
Abstract: Atherosclerosis is the most common cardiovascular disease and is the number one cause of death worldwide. Today, atherosclerosis is a multifactorial chronic inflammatory disease with an autoimmune component, accompanied by the accumulation of cholesterol in… read more here.
Keywords: cholesterol accumulation; accumulation cells; role; accumulation ... See more keywords
Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.45003
Abstract: Disturbed renal lipid metabolism, especially cholesterol dysregulation plays a crucial role in the pathogenesis of chronic kidney disease (CKD). We recently reported that angiotensin (Ang) II could induce cholesterol accumulation and injury in podocytes. However,… read more here.
Keywords: accumulation injury; sirt6; cholesterol accumulation; cholesterol ... See more keywords