A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.01.031
Abstract: The oligomeric organization of the voltage-dependent anion-selective channel (VDAC) and its interactions with hexokinase play integral roles in mitochondrially mediated apoptotic signaling. Various small to large assemblies of VDAC are observed in mitochondrial outer membranes,… read more here.
Keywords: cholesterol analog; analog induces; vdac; induces oligomeric ... See more keywords
A cholesterol analog stabilizes the human β2-adrenergic receptor nonlinearly with temperature
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abi7031
Abstract: In cell membranes, G protein–coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized… read more here.
Keywords: temperature; cholesterol; adrenergic receptor; cholesterol analog ... See more keywords