Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures.
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DOI: 10.1007/978-3-030-14265-0_4
Abstract: Cholesterol is a highly asymmetric lipid molecule. As an essential constituent of the cell membrane, cholesterol plays important structural and signaling roles in various biological processes. The first high-resolution crystal structure of a transmembrane protein… read more here.
Keywords: joint analysis; cholesterol binding; membrane proteins; cholesterol ... See more keywords
Insights into the Molecular Mechanisms of Cholesterol Binding to the NPC1 and NPC2 Proteins.
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DOI: 10.1007/978-3-030-14265-0_8
Abstract: In recent years, a growing number of studies have implicated the coordinated action of NPC1 and NPC2 in intralysosomal transport and efflux of cholesterol. Our current understanding of this process developed with just over two… read more here.
Keywords: cholesterol binding; transport; insights molecular; cholesterol ... See more keywords
Cholesterol Binding to the Transmembrane Region of a Group 2 Hemagglutinin (HA) of Influenza Virus Is Essential for Virus Replication, Affecting both Virus Assembly and HA Fusion Activity
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DOI: 10.1128/jvi.00555-19
Abstract: The glycoprotein HA is a major pathogenicity factor of influenza viruses. Whereas the structure and function of HA’s ectodomain is known in great detail, similar data for the membrane-anchoring part of the protein are missing.… read more here.
Keywords: cholesterol; membrane; virus replication; virus ... See more keywords
Common structural features of cholesterol binding sites in crystallized soluble proteins
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DOI: 10.1194/jlr.r073452
Abstract: Cholesterol-protein interactions are essential for the architectural organization of cell membranes and for lipid metabolism. While cholesterol-sensing motifs in transmembrane proteins have been identified, little is known about cholesterol recognition by soluble proteins. We reviewed… read more here.
Keywords: protein; cholesterol binding; features cholesterol; cholesterol ... See more keywords