Does Sirt2 Regulate Cholesterol Biosynthesis During Oligodendroglial Differentiation In Vitro and In Vivo?
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0537-6
Abstract: Sirtuin2 (SIRT2) is a deacetylase enzyme predominantly expressed in myelinating glia of the central nervous system (CNS). We have previously demonstrated that Sirt2 expression enhances oligodendrocyte (OL) differentiation and arborization in vitro, but the molecular… read more here.
Keywords: sirt2; cholesterol; cholesterol biosynthesis; expression ... See more keywords
Allantoin, a Potential Metabolite That Promotes AMPK Phosphorylation and Suppresses Cholesterol Biosynthesis Via the Mevalonate Pathway and Bloch Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-020-03265-2
Abstract: This study aimed to evaluate the effect of probiotic administration on obese and ageing models. Sprague Dawley rats were subjected to high-fat diet (HFD) and injected with D-galactose to induce premature ageing. Upon 12 weeks of… read more here.
Keywords: cholesterol biosynthesis; biosynthesis via; pathway; via mevalonate ... See more keywords
Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.085
Abstract: Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism… read more here.
Keywords: foam cell; formation; cholesterol biosynthesis; mice ... See more keywords
Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110423
Abstract: Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous loss of individual genes can result in different regional phenotypes. However, a molecular basis for these distinctions is unknown. Using single-cell analysis of oligodendroglia… read more here.
Keywords: cholesterol biosynthesis; brain; spinal cord; brain spinal ... See more keywords
Undaria pinnatifida (U. pinnatifida) bioactivity: Antioxidant, gastro-intestinal motility, cholesterol biosynthesis and liver cell lines proteome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104567
Abstract: Abstract Undaria pinnatifida is a brown alga, largely used as food in oriental countries. The purpose of this work was to analyze several bioactivities that might be present in different food preparations, relating them with… read more here.
Keywords: pinnatifida; cholesterol biosynthesis; undaria pinnatifida; gastro intestinal ... See more keywords
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105489
Abstract: Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process. Proper myelination is crucial for… read more here.
Keywords: hippocampal demyelination; demyelination; anxiety like; cholesterol ... See more keywords
CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01882-7
Abstract: Cancer stem cells (CSCs) are responsible for tumor progression, recurrence, and drug resistance. To identify genetic vulnerabilities of colon cancer, we performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on… read more here.
Keywords: cancer; cholesterol biosynthesis; colon cancer; colon ... See more keywords
Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Aging and Mechanisms of Disease"
DOI: 10.1038/s41514-021-00064-9
Abstract: The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying… read more here.
Keywords: brain cholesterol; disease; cholesterol; cholesterol biosynthesis ... See more keywords
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48972-x
Abstract: While evidence supporting the notion that exposures to heavy ion radiation increase the risk for cancer and other disease development is accumulating, the underlying biological mechanisms remain poorly understood. To identify novel phenotypes that persist… read more here.
Keywords: cholesterol levels; cholesterol; cholesterol biosynthesis; lung tissue ... See more keywords
Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00305f
Abstract: Methylglyoxal (MG) is a highly reactive dicarbonyl known to be elevated under the hyperglycemic conditions of diabetes and is implicated in the development of diabetic complications. Therefore, the current study investigates the role of MG… read more here.
Keywords: enzymes involved; cholesterol; cholesterol biosynthesis; involved cholesterol ... See more keywords
Cholesterol Biosynthesis Is Required for Cell Death in Response to G9A Inhibitor in Lung Cancer (P05-010-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz030.p05-010-19
Abstract: Objectives G9A is a eukaryotic histone methyltransferase that contributes to transcriptional silencing of tumor suppressor genes by modulating histone 3 lysine 9 methylation (H3K9m). It has been recently suggested as a promising therapeutic target for… read more here.
Keywords: cell death; cholesterol biosynthesis; lung cancer; g9a ... See more keywords