Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs
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DOI: 10.1093/nar/gky745
Abstract: Abstract Progress in oligonucleotide chemistry has produced a shift in the nature of siRNA used, from formulated, minimally modified siRNAs, to unformulated, heavily modified siRNA conjugates. The introduction of extensive chemical modifications is essential for… read more here.
Keywords: heavily modified; non modified; efficacy; cholesterol conjugated ... See more keywords