Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01186-z
Abstract: Endothelial cells (EC) play a key role in atherosclerosis. Although EC are in constant contact with low density lipoproteins (LDL), how EC process LDL and whether this influences atherogenesis, is unclear. Here we show that… read more here.
Keywords: cholesterol; cholesterol crystal; crystal production; hyperlipidemia induced ... See more keywords
Successful treatment of cholesterol crystal embolism with anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody: a case report
Sign Up to like & getrecommendations! Published in 2020 at "Renal Failure"
DOI: 10.1080/0886022x.2020.1726383
Abstract: Abstract Background We report a unique case of renal cholesterol crystal embolism (CCE) induced by carotid artery stenting that was successfully treated with evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin kexin type… read more here.
Keywords: crystal embolism; case; cholesterol; cholesterol crystal ... See more keywords
Efficacy of LDL apheresis for the treatment of cholesterol crystal embolism: A prospective, controlled study
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.13706
Abstract: This study was performed to evaluate the efficacy and safety of LDL apheresis (LDL‐A) for the treatment of cholesterol crystal embolism (CCE) after cardiovascular procedures. We conducted a prospective multicenter study of 34 patients with… read more here.
Keywords: cholesterol crystal; study; apheresis; crystal embolism ... See more keywords
Visible-free cholesterol crystal emboli adjacent to microinfarcts in myocardial capillaries and arterioles on H&E-stained frozen sections of an autopsied patient
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-225558
Abstract: The number of released free cholesterol crystal emboli (fCCE) and their role during percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) have not been documented yet. Furthermore, fCCE manifesting in the coronary lumen following… read more here.
Keywords: microscopy; cholesterol crystal; crystal emboli; free cholesterol ... See more keywords
Renal cholesterol crystal embolism in the setting of warfarin use
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2019-230314
Abstract: A 73-year-old man presented for evaluation of weakness and black tarry stools that occurred 1 day prior to admission. His medical history is significant for diabetes mellitus, stage 3 chronic kidney disease and deep vein thrombosis… read more here.
Keywords: warfarin use; warfarin; renal cholesterol; cholesterol crystal ... See more keywords
A Catastrophic Case of Idiopathic Cholesterol Crystal Embolism with Multiple Lethal Complications: A Labyrinth Underneath the Diagnosis of Skin Ulcers in Chronic Kidney Disease Patients
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.2378-18
Abstract: A 66-year-old man was admitted to our hospital because of multiple refractory skin ulcers. Based on his severe systemic arterial calcification and severe calcium-phosphate imbalance due to severe kidney dysfunction, we initially considered calciphylaxis. However,… read more here.
Keywords: chronic kidney; cholesterol; cholesterol crystal; skin ulcers ... See more keywords
Cholesterol Crystal-Mediated Inflammation Is Driven by Plasma Membrane Destabilization
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01163
Abstract: Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early in life, it progresses to plaque formation and form cell accumulation. A culprit in this cascade is the deposition of… read more here.
Keywords: crystal mediated; cholesterol crystal; cell; membrane ... See more keywords