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Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2661
Abstract: The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol‐rich membranes, where they…
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Keywords:
dependent cytolysins;
outstanding questions;
cytolysins outstanding;
cholesterol dependent ... See more keywords
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Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00878-7
Abstract: G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins that relay extracellular signals across the plasma membrane and elicit an intricate cascade of cellular signaling events. A significantly large fraction of available drugs…
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Keywords:
dependent endocytosis;
endocytosis gpcrs;
membrane;
gpcrs ... See more keywords
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Published in 2017 at "Nano letters"
DOI: 10.1021/acs.nanolett.7b02973
Abstract: Optical nanoantennas can efficiently confine light into nanoscopic hotspots, enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual…
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Keywords:
membrane living;
optical nanoantennas;
cholesterol;
cholesterol dependent ... See more keywords
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Published in 2022 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-021-00827-0
Abstract: Cholesterol is a critical lipid for all mammalian cells, ensuring proper membrane integrity, fluidity, and biochemical function. Accumulating evidence indicates that macrophages rapidly and profoundly reprogram their cholesterol metabolism in response to activation signals to…
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Keywords:
dependent cytolysins;
cholesterol;
cholesterol dependent;
host defense ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14002-x
Abstract: Cholesterol distribution in the cell is maintained by both vesicular and non-vesicular sterol transport. Non-vesicular transport is mediated by the interaction of membrane-embedded cholesterol and water-soluble proteins. Small changes to the lipid composition of the…
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Keywords:
cholesterol content;
perfringolysin;
cholesterol;
cholesterol dependent ... See more keywords
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Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001279
Abstract: One-third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis. This reservoir of bacteria is largely resistant to antimicrobial treatment that often only targets actively replicating mycobacteria, with current treatment for…
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Keywords:
non replicating;
dapsone;
activity;
cholesterol dependent ... See more keywords
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Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.691731
Abstract: Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the mechanisms associated with T. pallidum traversal of endothelial barriers. Immunofluorescence microscopy…
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Keywords:
treponema pallidum;
intercellular junctions;
cholesterol dependent;
traverses endothelial ... See more keywords
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Published in 2022 at "Toxins"
DOI: 10.3390/toxins15010004
Abstract: The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to…
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Keywords:
extracellular vesicles;
repair proteins;
dependent cytolysins;
cholesterol dependent ... See more keywords