Cholesterol‐dependent cytolysins: The outstanding questions
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2661
Abstract: The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol‐rich membranes, where they… read more here.
Keywords: dependent cytolysins; outstanding questions; cytolysins outstanding; cholesterol dependent ... See more keywords
Cholesterol-dependent endocytosis of GPCRs: implications in pathophysiology and therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00878-7
Abstract: G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins that relay extracellular signals across the plasma membrane and elicit an intricate cascade of cellular signaling events. A significantly large fraction of available drugs… read more here.
Keywords: dependent endocytosis; endocytosis gpcrs; membrane; gpcrs ... See more keywords
Planar Optical Nanoantennas Resolve Cholesterol-Dependent Nanoscale Heterogeneities in the Plasma Membrane of Living Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Nano letters"
DOI: 10.1021/acs.nanolett.7b02973
Abstract: Optical nanoantennas can efficiently confine light into nanoscopic hotspots, enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual… read more here.
Keywords: membrane living; optical nanoantennas; cholesterol; cholesterol dependent ... See more keywords
Cholesterol-Dependent Membrane Deformation by Metastable Viral Capsids Facilitates Entry.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.4c00085
Abstract: Nonenveloped viruses employ unique entry mechanisms to breach and infect host cells. Understanding these mechanisms is crucial for developing antiviral strategies. Prevailing perspective suggests that nonenveloped viruses release membrane pore-forming peptides to breach host membranes.… read more here.
Keywords: dependent membrane; metastable viral; viral capsids; cholesterol dependent ... See more keywords
Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-021-00827-0
Abstract: Cholesterol is a critical lipid for all mammalian cells, ensuring proper membrane integrity, fluidity, and biochemical function. Accumulating evidence indicates that macrophages rapidly and profoundly reprogram their cholesterol metabolism in response to activation signals to… read more here.
Keywords: dependent cytolysins; cholesterol; cholesterol dependent; host defense ... See more keywords
Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14002-x
Abstract: Cholesterol distribution in the cell is maintained by both vesicular and non-vesicular sterol transport. Non-vesicular transport is mediated by the interaction of membrane-embedded cholesterol and water-soluble proteins. Small changes to the lipid composition of the… read more here.
Keywords: cholesterol content; perfringolysin; cholesterol; cholesterol dependent ... See more keywords
Cholesterol-dependent enzyme activity of human TSPO1
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2323045122
Abstract: Significance The function and structure of the tryptophan-rich sensory proteins (TSPO) family have been the subject of contention. Here, we describe the finding of human mitochondrial TSPO1 as a cholesterol-dependent enzyme. This finding establishes the… read more here.
Keywords: cholesterol dependent; tspo1; human tspo1; dependent enzyme ... See more keywords
Cholesterol-dependent activity of dapsone against non-replicating persistent mycobacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001279
Abstract: One-third of the world's population is estimated to be latently infected with Mycobacterium tuberculosis. This reservoir of bacteria is largely resistant to antimicrobial treatment that often only targets actively replicating mycobacteria, with current treatment for… read more here.
Keywords: non replicating; dapsone; activity; cholesterol dependent ... See more keywords
Treponema pallidum Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.691731
Abstract: Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the mechanisms associated with T. pallidum traversal of endothelial barriers. Immunofluorescence microscopy… read more here.
Keywords: treponema pallidum; intercellular junctions; cholesterol dependent; traverses endothelial ... See more keywords
Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins15010004
Abstract: The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to… read more here.
Keywords: extracellular vesicles; repair proteins; dependent cytolysins; cholesterol dependent ... See more keywords