Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100941
Abstract: Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols… read more here.
Keywords: phase; phase separation; cholesterol disordered; disordered domains ... See more keywords