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   Articles with "cholesterol efflux" as a keyword



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Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A‐I [Human]) to Enhance Cholesterol Efflux Capacity

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recommendations! Published in 2019 at "Journal of Clinical Pharmacology"

DOI: 10.1002/jcph.1337

Abstract: CSL112 (apolipoprotein A‐I [human]) is a novel intravenous formulation of plasma‐derived apolipoprotein A‐I (apoA‐I) that enhances cholesterol efflux capacity. Renal impairment is a common comorbidity in acute myocardial infarction patients and is associated with impaired… read more here.

Keywords: moderate renal; csl112; renal impairment; efflux capacity ... See more keywords
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Monitoring Atheroprotective Macrophage Cholesterol Efflux In Vivo.

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recommendations! Published in 2022 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1924-7_35

Abstract: This chapter provides details on the methodologies currently used to monitor macrophage cholesterol efflux in vivo in mice. The general principles and techniques described herein can be applied to evaluate the effect of different experimental… read more here.

Keywords: monitoring atheroprotective; cholesterol; efflux vivo; cholesterol efflux ... See more keywords
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Insulin Rescued MCP-1-Suppressed Cholesterol Efflux to Large HDL2 Particles via ABCA1, ABCG1, SR-BI and PI3K/Akt Activation in Adipocytes

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recommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"

DOI: 10.1007/s10557-021-07166-2

Abstract: Intracellular cholesterol imbalance plays an important role in adipocyte dysfunction of obesity. However, it is unclear whether obesity induced monocyte chemoattractant protein-1 (MCP-1) causes the adipocyte cholesterol imbalance. In this study, we hypothesize that MCP-1… read more here.

Keywords: hdl2 particles; large hdl2; cholesterol; mcp ... See more keywords
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Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway.

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recommendations! Published in 2020 at "Archives of pharmacal research"

DOI: 10.1007/s12272-020-01255-w

Abstract: LXRα agonists have attracted significant attention due to their potential biological activities on promoting cholesterol efflux. This study was designed to investigate whether setosphapyrone C and D have potential lipid-lowering capacity and the underlying mechanisms… read more here.

Keywords: setosphapyrone significantly; setosphapyrone accelerate; setosphapyrone; significantly enhanced ... See more keywords
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CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1.

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recommendations! Published in 2022 at "Journal of physiology and biochemistry"

DOI: 10.1007/s13105-022-00885-6

Abstract: C1q tumor necrosis factor-related protein 15 (CTRP15), a newly identified myokine, is closely implicated in cardiovascular disease. However, the role of CTRP15 in atherosclerosis is still unclear. This study aims to determine the role of… read more here.

Keywords: expression; cholesterol; ctrp15 promotes; cholesterol efflux ... See more keywords
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HDL cholesterol efflux capacity and cholesteryl ester transfer are associated with body mass, but are not changed by diet-induced weight loss: A randomized trial in abdominally obese men.

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recommendations! Published in 2018 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2018.04.029

Abstract: BACKGROUND AND AIMS Obesity is associated with a lower HDL-mediated cholesterol efflux from macrophages and a higher CETP (cholesteryl ester transfer protein) activity, but effects of weight loss are not clear. In addition, associations with… read more here.

Keywords: abdominally obese; weight loss; transfer; cholesterol efflux ... See more keywords
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An octimibate derivative, Oxa17, enhances cholesterol efflux and exerts anti-inflammatory and atheroprotective effects in experimental atherosclerosis.

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recommendations! Published in 2021 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2021.114581

Abstract: Atherosclerotic cardiovascular diseases (ASCVDs), associated with vascular inflammation and lipid dysregulation, are responsible for high morbidity and mortality rates globally. For ASCVD treatment, cholesterol efflux plays an atheroprotective role in ameliorating inflammation and lipid dysregulation.… read more here.

Keywords: anti inflammatory; octimibate derivative; derivative oxa17; atherosclerosis ... See more keywords
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Mechanisms of antidiabetic drugs and cholesterol efflux: a clinical perspective.

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recommendations! Published in 2022 at "Drug discovery today"

DOI: 10.1016/j.drudis.2022.02.006

Abstract: Reverse cholesterol transport (RCT) is a physiological process that reduces excess cholesterol in the body. Cholesterol efflux (CE), an important step in RCT, is mainly mediated by ATP-binding cassette transporters A1 and G1 and has… read more here.

Keywords: antidiabetic drugs; efflux clinical; cholesterol; drugs cholesterol ... See more keywords
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Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages.

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recommendations! Published in 2017 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2017.05.055

Abstract: It was reported that puerarin decreases the total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and increases high-density lipoprotein cholesterol (HDL-C) level, but the underlying mechanism is unclear. This study was designed to determine whether… read more here.

Keywords: lipid accumulation; abca1 mediated; cholesterol; mediated cholesterol ... See more keywords
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Disentangling The Shared Genetic Etiology Between Serum Cholesterol And Suicide Risk: A Potential Moderating Role For Cholesterol Efflux

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recommendations! Published in 2017 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2016.09.588

Abstract: Background The link between serum cholesterol and suicide attempts is well established, several studies suggest that lower levels of cholesterol are associated with increased risk of mortality from suicide. However, the etiology of this association… read more here.

Keywords: etiology; cholesterol; cholesterol efflux; free cholesterol ... See more keywords
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microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.11.058

Abstract: Macrophage foam cell formation is a key initiating event in the pathogenesis of atherosclerosis. This work was conducted to determine the role of microRNA (miR)-212 in the transformation of foam cells from macrophages. We examined… read more here.

Keywords: sirt1; lipid accumulation; mir 212; thp macrophages ... See more keywords