Endolysosomal cholesterol export: More than just NPC1
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DOI: 10.1002/bies.202200111
Abstract: NPC1 plays a central role in cholesterol egress from endolysosomes, a critical step for maintaining intracellular cholesterol homeostasis. Despite recent advances in the field, the full repertoire of molecules and pathways involved in this process… read more here.
Keywords: export npc1; cholesterol; cholesterol export; endolysosomal cholesterol ... See more keywords
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
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DOI: 10.7554/elife.38564
Abstract: Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when… read more here.
Keywords: lysosomal cholesterol; cholesterol; cholesterol export; npc1 ... See more keywords