Glucagon-like peptide-1 contributes to increases ABCA1 expression by downregulating miR-758 to regulate cholesterol homeostasis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.126
Abstract: Abnormal regulation of lipid metabolism is associated with type 2 diabetes mellitus (T2DM). GLP-1 as a new treatment for T2DM, has unique effects in modulating cholesterol homeostasis. However, the mechanism of this effect is largely… read more here.
Keywords: mir 758; abca1 expression; cholesterol homeostasis; cholesterol ... See more keywords
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.06.003
Abstract: Unbiased profiling approaches are powerful tools for small-molecule target or mode-of-action deconvolution as they generate a holistic view of the bioactivity space. This is particularly important for non-protein targets that are difficult to identify with… read more here.
Keywords: homeostasis; identification; cholesterol homeostasis; proteome profiling ... See more keywords
Eukaryotic Clathrin Adapter Protein and Mediator of Cholesterol Homeostasis, PICALM, Affects Trafficking to the Chlamydial Inclusion
Sign Up to like & getrecommendations! Published in 2023 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2023.2171695
Abstract: Abstract The obligate intracellular pathogen Chlamydia trachomatis has unique metabolic requirements as it proceeds through its biphasic developmental cycle from within the inclusion within the host cell. In our previous study, we identified a host… read more here.
Keywords: picalm; chlamydial inclusion; cholesterol homeostasis; inclusion ... See more keywords
SUMOylation in the control of cholesterol homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Open Biology"
DOI: 10.1098/rsob.200054
Abstract: SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for… read more here.
Keywords: homeostasis; control cholesterol; sumoylation control; cholesterol homeostasis ... See more keywords
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.05.490737
Abstract: There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes, however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to… read more here.
Keywords: endothelial cells; accessible cholesterol; cholesterol homeostasis; cholesterol ... See more keywords
Assessment of cholesterol homeostasis in the living human brain
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adc9967
Abstract: Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via… read more here.
Keywords: cholesterol metabolism; brain cholesterol; brain; cholesterol homeostasis ... See more keywords
Impact of Impaired Cholesterol Homeostasis on Neutrophils in Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.123.316246
Abstract: Atherosclerosis is complex chronic disease characterized by intimal cholesterol accumulation and vascular inflammation. There is a well-established relationship of hypercholesterolemia and inflammation with atherosclerosis. However, the link between inflammation and cholesterol is not completely understood.… read more here.
Keywords: impaired cholesterol; impact impaired; cholesterol homeostasis; atherosclerosis ... See more keywords
Targeting cholesterol homeostasis in hematopoietic malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2021012788
Abstract: Cholesterol is a vital lipid for cellular functions. It is necessary for membrane biogenesis, cell proliferation and differentiation. In addition to maintaining cell integrity and permeability, increasing evidence indicates a strict link between cholesterol homeostasis,… read more here.
Keywords: homeostasis hematopoietic; cholesterol homeostasis; cholesterol; targeting cholesterol ... See more keywords
Cellular cholesterol homeostasis and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.r075630
Abstract: Alzheimer’s disease (AD) is the most common form of dementia in older adults. Currently, there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid plaques composed of amyloid-β (Aβ)… read more here.
Keywords: alzheimer disease; cholesterol homeostasis; cholesterol; cellular cholesterol ... See more keywords
TMEM147 interacts with Lamin B Receptor, regulates its localization and levels, and affects cholesterol homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.245357
Abstract: The structurally and functionally complex Endoplasmic Reticulum (ER) hosts critical processes including lipid synthesis. Here, we focus on the functional characterization of transmembrane protein TMEM147 and report that it localizes at the ER and nuclear… read more here.
Keywords: lamin receptor; lbr; cholesterol homeostasis; tmem147 ... See more keywords
Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17485
Abstract: Tuberous sclerosis complex (TSC) is a multisystem disease associated with hyperactive mTORC1. The impact of TSC1/2 deficiency on lysosome-mediated processes is not fully understood. We report here that inhibition of lysosomal function using chloroquine (CQ)… read more here.
Keywords: tuberous sclerosis; sclerosis complex; cholesterol homeostasis; cholesterol ... See more keywords