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   Articles with "cholesterol homeostasis" as a keyword



NXT629 Ameliorates Cholesterol Gallstones in Mice Model by Improving Lipid Metabolism Disorder and Cholesterol Homeostasis Through Inhibiting the GPAM Pathway

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recommendations! Published in 2024 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-024-08798-8

Abstract: NXT629, a PPAR-alpha antagonist, exerts widespread effects in many diseases; however, its function and relevant mechanism in cholesterol gallstones (CG) remain largely unknown. Male C57BL/6 J mice were fed a regular diet or lithogenic diet… read more here.

Keywords: cholesterol homeostasis; cholesterol gallstones; lipid metabolism; nxt629 ... See more keywords

Glucagon-like peptide-1 contributes to increases ABCA1 expression by downregulating miR-758 to regulate cholesterol homeostasis.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.02.126

Abstract: Abnormal regulation of lipid metabolism is associated with type 2 diabetes mellitus (T2DM). GLP-1 as a new treatment for T2DM, has unique effects in modulating cholesterol homeostasis. However, the mechanism of this effect is largely… read more here.

Keywords: mir 758; abca1 expression; cholesterol homeostasis; cholesterol ... See more keywords
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Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis.

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recommendations! Published in 2021 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2021.06.003

Abstract: Unbiased profiling approaches are powerful tools for small-molecule target or mode-of-action deconvolution as they generate a holistic view of the bioactivity space. This is particularly important for non-protein targets that are difficult to identify with… read more here.

Keywords: homeostasis; identification; cholesterol homeostasis; proteome profiling ... See more keywords

Cadmium Exposure Promotes Atherosclerosis by Disrupting Cholesterol Homeostasis via miR-30d-5p Regulation.

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recommendations! Published in 2025 at "Environmental science & technology"

DOI: 10.1021/acs.est.5c07383

Abstract: Cadmium (Cd) exposure is an emerging environmental risk factor for atherosclerotic cardiovascular diseases (ASCVDs), particularly ischemic stroke (IS). MicroRNAs are potential mediators linking environmental exposure to health hazards. However, the role of miRNAs in the… read more here.

Keywords: cadmium exposure; exposure; cholesterol homeostasis; mir 30d ... See more keywords

Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease

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recommendations! Published in 2024 at "Biochemical Society Transactions"

DOI: 10.1042/bst20231359

Abstract: Underexpression, overexpression, and point mutations in peripheral myelin protein 22 (PMP22) cause most cases of Charcot-Marie-Tooth disease (CMTD). While its exact functions remain unclear, PMP22 is clearly essential for formation and maintenance of healthy myelin… read more here.

Keywords: pmp22 cholesterol; disease; cholesterol homeostasis; roles pmp22 ... See more keywords

Eukaryotic Clathrin Adapter Protein and Mediator of Cholesterol Homeostasis, PICALM, Affects Trafficking to the Chlamydial Inclusion

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recommendations! Published in 2023 at "Molecular and Cellular Biology"

DOI: 10.1080/10985549.2023.2171695

Abstract: Abstract The obligate intracellular pathogen Chlamydia trachomatis has unique metabolic requirements as it proceeds through its biphasic developmental cycle from within the inclusion within the host cell. In our previous study, we identified a host… read more here.

Keywords: picalm; chlamydial inclusion; cholesterol homeostasis; inclusion ... See more keywords

Potential function of hepatic Niemann–Pick C1-like 1: cholesterol homeostasis regulation of the canalicular lipid bilayer membrane

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recommendations! Published in 2025 at "Gastroenterology Report"

DOI: 10.1093/gastro/goaf010

Abstract: Abstract Niemann–Pick C1-like 1 (NPC1L1) is distributed in the human liver and intestine but only slightly expressed in the mouse liver. While it is well established that intestinal NPC1L1 is crucial for the absorption of… read more here.

Keywords: pick like; cholesterol homeostasis; potential function; niemann pick ... See more keywords

SUMOylation in the control of cholesterol homeostasis

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recommendations! Published in 2020 at "Open Biology"

DOI: 10.1098/rsob.200054

Abstract: SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for… read more here.

Keywords: homeostasis; control cholesterol; sumoylation control; cholesterol homeostasis ... See more keywords

Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.05.05.490737

Abstract: There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes, however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to… read more here.

Keywords: endothelial cells; accessible cholesterol; cholesterol homeostasis; cholesterol ... See more keywords

Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adr5703

Abstract: Neurodegeneration is a devastating manifestation in most lysosomal storage disorders (LSDs). Loss-of-function mutations in CLN1, encoding palmitoyl-protein thioesterase-1 (PPT1), cause CLN1 disease, a devastating neurodegenerative LSD that has no curative treatment. Numerous proteins in the… read more here.

Keywords: disease; cholesterol homeostasis; cln1; lysosomal cholesterol ... See more keywords

Assessment of cholesterol homeostasis in the living human brain

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recommendations! Published in 2022 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.adc9967

Abstract: Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via… read more here.

Keywords: cholesterol metabolism; brain cholesterol; brain; cholesterol homeostasis ... See more keywords