Cholesterol‐24‐hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25436
Abstract: Cholesterol‐24‐hydroxylase (CYP46), a member of the cytochrome P450 superfamily of enzymes, is selectively expressed in the brain and is mainly responsible for cholesterol turnover in the central nervous system. Although increased cyp46A1 gene expression has… read more here.
Keywords: cholesterol hydroxylase; brain; hydroxylase cyp46; expression ... See more keywords
Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3‐mediated hepatocyte nuclear receptor 4α/cholesterol 7α‐hydroxylase pathway in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28928
Abstract: Prostaglandin E2 (PGE2) is an important lipid mediator of inflammation. However, whether and how PGE2 regulates hepatic cholesterol metabolism remains unknown. We found that expression of the PGE2 receptor, E prostanoid receptor 3 (EP3) expression… read more here.
Keywords: prostanoid receptor; cholesterol; mice; receptor ... See more keywords
Expression of Cholesterol Hydroxylase/Lyase System Proteins in Yeast S. cerevisiae Cells as a Self-Processing Polyprotein
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0028-5
Abstract: Abstract2A peptide discovered in Picornaviridae is capable of self-cleavage providing an opportunity to carry out synthesis of several proteins using one transcript. Dissociation in the 2A sequence during translation leads to the individual proteins formation.… read more here.
Keywords: cholesterol hydroxylase; hydroxylase lyase; system;
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00377-9
Abstract: Cholesterol-25-hydroxylase (CH25H) is a membrane protein associated with endoplasmic reticulum, and it is an interferon-stimulated factor regulated by interferon. CH25H catalyzes cholesterol to produce 25-hydroxycholesterol (25HC) by adding a second hydroxyl to the 25th carbon… read more here.
Keywords: adsorption; ch25h; cholesterol; cholesterol hydroxylase ... See more keywords
Macrophage Migration Inhibitory Factor Promotes Chemotaxis of Astrocytes through Regulation of Cholesterol 25-Hydroxylase Following Rat Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.04.022
Abstract: Oxysterol derived from cholesterol metabolism is involved in the inflammatory activation, and consequently in development of major chronic diseases. Multiple cytokines have been found to induce the expression of cholesterol metabolism-related enzymes. Several studies have… read more here.
Keywords: regulation cholesterol; cholesterol; expression; cholesterol hydroxylase ... See more keywords
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01898
Abstract: Cholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis. For the development of a novel and potent CH24H inhibitor, we designed and… read more here.
Keywords: cholesterol hydroxylase; ch24h; pyridine derivatives; hydroxylase ch24h ... See more keywords
Up-regulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric research"
DOI: 10.1038/pr.2018.49
Abstract: BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the… read more here.
Keywords: hypoxia ischemia; brain cholesterol; cholesterol; cholesterol hydroxylase ... See more keywords
Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13517
Abstract: Soticlestat is a first-in-class, selective inhibitor of cholesterol 24-hydroxylase (CH24H), which catabolizes cholesterol to 24S-hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox-Gastaut syndrome treatment. This study aimed to develop… read more here.
Keywords: cholesterol hydroxylase; soticlestat; 24s hydroxycholesterol; model ... See more keywords
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17232
Abstract: OBJECTIVE The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalysed by cholesterol 24-hydroxylase (CYP46A1 also known as CH24H). CH24H has been implicated in various biological mechanisms whereas pharmacological lowering of 24S-hydroxycholesterol has… read more here.
Keywords: 24s hydroxycholesterol; cholesterol; soticlestat novel; cholesterol hydroxylase ... See more keywords
Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice[S]
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m074534
Abstract: Both iron and lipids are involved in the progression of alcoholic fatty liver disease (AFLD), but the interaction between iron and lipids in AFLD is unclear. Here, we tested the hypothesis that iron regulates the… read more here.
Keywords: cholesterol hydroxylase; noncanonical ire; ire; expression ... See more keywords
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4137501
Abstract: Cholesterol 24-hydroxylase (CH24H, CYP46A1) is a cytochrome P450 family enzyme that maintains the homeostasis of brain cholesterol. Soticlestat, a potent and selective CH24H inhibitor, is in development as a therapeutic agent for Dravet syndrome and… read more here.
Keywords: cholesterol hydroxylase; ch24h; pet; pet tracers ... See more keywords