Cholesterol Metabolism Modulation Nanoplatform Improves Photo-Immunotherapeutic Effect In Oral Squamous Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300018
Abstract: Impressive results in cancer treatment have been obtained through immunotherapy. However, abnormally high cholesterol metabolism in the tumor microenvironment (TME) leads to poor immunogenicity or even immunosuppression, which dramatically reduces the clinical response of patients… read more here.
Keywords: cell; cholesterol metabolism; squamous cell; oral squamous ... See more keywords
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70783
Abstract: Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating… read more here.
Keywords: regulation tumor; role cholesterol; tumor; metabolism regulation ... See more keywords
Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3358
Abstract: Metabolic disorders are often associated with liver steatosis and increased plasma cholesterol levels. However, the link between excessive lipid accumulation and impairments in cholesterol metabolism remains uninvestigated in the liver. Short term of high‐fat diet… read more here.
Keywords: hfd; cholesterol metabolism; cholesterol; involved cholesterol ... See more keywords
Central nervous system cholesterol metabolism in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2662
Abstract: Cholesterol is a ubiquitous and essential component of cellular membranes, as it regulates membrane structure and fluidity. Furthermore, cholesterol serves as a precursor for steroid hormones, oxysterol, and bile acids, that are essential for maintaining… read more here.
Keywords: metabolism; cholesterol metabolism; central nervous; cholesterol ... See more keywords
Mechanisms of Sigma‐2/TMEM97 Involvement in Cholesterol Metabolism
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30645
Abstract: Extensive research has focused on cellular cholesterol and its regulation, primarily due to its crucial physiological roles and its association with numerous diseases resulting from dysregulated homeostasis. Consequently, investigating cholesterol metabolism and the network of… read more here.
Keywords: mechanisms sigma; sigma tmem97; tmem97 involvement; cholesterol metabolism ... See more keywords
Relative variations of gut microbiota in disordered cholesterol metabolism caused by high‐cholesterol diet and host genetics
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DOI: 10.1002/mbo3.491
Abstract: Recent studies performed provide mechanistic insight into effects of the microbiota on cholesterol metabolism, but less focus was given to how cholesterol impacts the gut microbiota. In this study, ApoE−/− Sprague Dawley (SD) rats and… read more here.
Keywords: cholesterol metabolism; genetics; gut microbiota; cholesterol ... See more keywords
The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1254-0
Abstract: An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and… read more here.
Keywords: cholesterol metabolism; cholesterol; interplay among; among hepatocytes ... See more keywords
The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02211-x
Abstract: The occurrence of Alzheimer's disease (AD) worldwide has been progressively accelerating at an alarming rate, without any successful therapeutic strategy for the disease mitigation. The complexity of AD pathogenesis needs to be targeted with an… read more here.
Keywords: cholesterol metabolism; alzheimer disease; abc transporters; disease ... See more keywords
Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.09.017
Abstract: BACKGROUND AND AIMS The profile of cholesterol metabolism, i.e., high absorption vs. high synthesis, may have a role in the development of atherosclerosis, the early lesions of which can be present already in childhood. Since… read more here.
Keywords: non cholesterol; age; serum non; cholesterol metabolism ... See more keywords
Monogenetic disorders of the cholesterol metabolism and premature cardiovascular disease
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.09.046
Abstract: Abstract Cholesterol is of vital importance for normal function of organisms. However, a high serum level is associated with an increased risk of cardiovascular disease. In this review an overview is presented of the different… read more here.
Keywords: premature cardiovascular; cholesterol metabolism; monogenetic disorders; disease ... See more keywords
Effects of Rosuvastatin on the expression of the genes involved in cholesterol metabolism in rats: adaptive responses by extrahepatic tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.03.092
Abstract: BACKGROUND Statins mostly target the liver; therefore, increase in the synthesis of cholesterol by extra-hepatic tissues and then transferring this cholesterol to the liver can be regarded as adaptive responses by these tissues. In addition… read more here.
Keywords: adaptive responses; cholesterol metabolism; hmgcr; cholesterol ... See more keywords