In silico studies of interactions of peptide-conjugated cholesterol metabolites and betulinic acid with EGFR, LDR, and N-terminal fragment of CCKA receptors
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DOI: 10.1007/s00894-021-05007-5
Abstract: In this work, we designed three new ligands by conjugating cholesterol metabolites 3-hydroxy-5-cholestenoic acid (3-HC) and 3-oxo-4-cholestenoic acid (3-OC) and the natural tri-terpenoid betulinic acid with the tumor-targeting peptide YHWYGYTPQNVI. Molecular interactions with the unconjugated… read more here.
Keywords: betulinic acid; cholesterol metabolites; acid; ccka ... See more keywords
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis
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DOI: 10.3389/fendo.2019.00204
Abstract: Hematopoiesis is sustained throughout life by hematopoietic stem cells (HSCs) that are capable of self-renewal and differentiation into hematopoietic progenitor cells (HPCs). There is accumulating evidence that cholesterol homeostasis is an important factor in the… read more here.
Keywords: hematopoiesis; normal malignant; cholesterol; metabolites normal ... See more keywords
Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage
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DOI: 10.3390/metabo11010009
Abstract: Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved… read more here.
Keywords: hydroxycholesterol; hydroxycholesterol sulfate; metabolites hydroxycholesterol; hydroxycholesterol hydroxycholesterol ... See more keywords