The effect of cholesterol overload on mouse kidney and kidney-derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Renal Failure"
DOI: 10.1080/0886022x.2017.1419974
Abstract: Abstract Introduction: Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has… read more here.
Keywords: kidney derived; cholesterol overload; cholesterol; megalin ... See more keywords
Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Reports"
DOI: 10.15252/embr.201847055
Abstract: Abstract Most cells acquire cholesterol by endocytosis of circulating low‐density lipoproteins (LDLs). After cholesteryl ester de‐esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional… read more here.
Keywords: lysobisphosphatidic acid; cholesterol overload; cholesterol; pick type ... See more keywords