High prevalence of cholesterol-rich atherosclerotic lesions in ancient mummies: A near-infrared spectroscopy study.
Sign Up to like & getrecommendations! Published in 2019 at "American heart journal"
DOI: 10.1016/j.ahj.2019.06.018
Abstract: Computed tomography has been used previously in mummies to detect arterial calcification, which is a marker of later-stage atherosclerosis. Here, using the novel approach of near-infrared spectroscopy, we detected cholesterol-rich atherosclerotic plaques in arterial samples… read more here.
Keywords: spectroscopy; near infrared; infrared spectroscopy; cholesterol rich ... See more keywords
Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217561120
Abstract: Tight junctions (TJs) are cell-adhesion structures responsible for the epithelial barrier. We reported that accumulation of cholesterol at the apical junctions is required for TJ formation [K. Shigetomi, Y. Ono, T. Inai, J. Ikenouchi, J.… read more here.
Keywords: apical junctions; cholesterol rich; rich domain; formation cholesterol ... See more keywords
Structure-function analysis of human stomatin: A mutation study
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DOI: 10.1371/journal.pone.0178646
Abstract: Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily including stomatin-like proteins, prohibitins, flotillin/reggie proteins, bacterial HflK/C proteins and erlins.… read more here.
Keywords: stomatin; cholesterol rich; structure function; structure ... See more keywords
Caveolin-1 Endows Order in Cholesterol-Rich Detergent Resistant Membranes
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DOI: 10.3390/biom9070287
Abstract: Cholesterol-enriched functional portions of plasma membranes, such as caveolae and rafts, were isolated from lungs of wild-type (WT) and caveolin-1 knockout (Cav-1 KO) mice within detergent resistant membranes (DRMs). To gain insight into their molecular… read more here.
Keywords: resistant membranes; cholesterol; caveolin; cholesterol rich ... See more keywords
Cholesterol-Rich Microdomains Contribute to PAR1 Signaling in Platelets Despite a Weak Localization of the Receptor in These Microdomains
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218065
Abstract: Platelet protease-activated receptor 1 (PAR1) is a cell surface G-protein-coupled receptor (GPCR) that acts as a thrombin receptor promoting platelet aggregation. Targeting the PAR1 pathway by vorapaxar, a PAR1 antagonist, leads to a reduction in… read more here.
Keywords: par1; rich microdomains; cholesterol; cholesterol rich ... See more keywords