Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146378
Abstract: Cholesterol sulfate (CS) is one of the most important known sterol sulfates in human plasma and it is present as a normal constituent in a variety of human tissues. In both the brain and periphery,… read more here.
Keywords: astrocyte metabolism; cell; metabolism; cholesterol sulfate ... See more keywords
Multimodal, in-situ imaging of ex-vivo human skin reveals decrease of cholesterol sulfate in the neoepithelium during acute wound healing.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04542
Abstract: Skin repair is a significant aspect of human health. While the makeup of healthy stratum corneum and epidermis is generally understood, the mobilization of molecular components during skin repair remains largely unknown. In the present… read more here.
Keywords: cholesterol sulfate; acute wound; skin; cholesterol ... See more keywords
An eye to evading the immune system
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DOI: 10.1126/science.361.6401.463-s
Abstract: Inflammation Some tissues, such as the eye, limit immune cell infiltration. Sakurai et al. found that a modified form of cholesterol inhibited the guanine nucleotide exchange factor DOCK2 and thus suppressed neutrophil and T cell… read more here.
Keywords: cholesterol sulfate; immune system; evading immune; eye evading ... See more keywords
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao4874
Abstract: A modified form of cholesterol protects the eye from immune cell invasion by inhibiting the Rac-specific GEF DOCK2. Evading the immune system with a lipid Some tissues, such as the eye, locally suppress immune cells… read more here.
Keywords: immune; dock2; cholesterol sulfate; cholesterol ... See more keywords