Recent developments in the regulation of cholesterol transport by natural molecules
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7198
Abstract: The dysregulation of cholesterol metabolism is a high‐risk factor for non‐alcoholic fatty liver disease (NAFLD), dyslipidemia, and atherosclerosis (AS). Cholesterol transport maintains whole‐body cholesterol homeostasis. Low‐density apolipoprotein receptor (LDLR) mediates cholesterol uptake in cells and… read more here.
Keywords: regulation cholesterol; transport natural; cholesterol; natural molecules ... See more keywords
Measurement of Macrophage-Specific In Vivo Reverse Cholesterol Transport in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6875-6_21
Abstract: Reverse cholesterol transport (RCT) is one of the main processes that is thought to protect against cardiovascular disease. RCT constitutes the removal of cholesterol from peripheral sites, its transport through the plasma compartment for delivery… read more here.
Keywords: cholesterol transport; reverse cholesterol; cholesterol; vivo ... See more keywords
Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nutrition"
DOI: 10.1007/s00394-017-1506-z
Abstract: PurposesWe previously showed that polyphenol-rich blackcurrant extract (BCE) showed a hypocholesterolemic effect in mice fed a high fat diet. As direct cholesterol removal from the body via the intestine has been recently appreciated, we investigated… read more here.
Keywords: bce; caco cells; transport; cholesterol ... See more keywords
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-019-9569-9
Abstract: Most mammalian cells take up cholesterol from low-density lipoproteins (LDLs) via receptor-mediated endocytosis. After reaching lysosomes, LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs. Peroxisomes are… read more here.
Keywords: peroxisome membrane; cholesterol transport; membrane; membrane contacts ... See more keywords
Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.109
Abstract: Atherosclerosis is characterized by the accumulation of excess cholesterol in plaques. Reverse cholesterol transport (RCT) plays a key role in the removal of cholesterol. In the present study, we examined the effect of thioredoxin-1 (Trx-1)… read more here.
Keywords: protects liver; liver steatosis; reverse cholesterol; cholesterol ... See more keywords
Vectorial Cholesterol Transport by STARD4 is Mediated by Specific PIP2 Membrane Composition
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.511
Abstract: STARD4 (steroidogenic acute regulatory protein-related lipid-transfer domain containing 4) is known to transport cholesterol from the plasma membrane (PM) to intracellular organelles, such as the endoplasmic reticulum and endocytic recycling compartment, but it has not… read more here.
Keywords: stard4; transport; vectorial cholesterol; cholesterol transport ... See more keywords
Persimmon tannin promoted macrophage reverse cholesterol transport through inhibiting ERK1/2 and activating PPARγ both in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.09.023
Abstract: Abstract The purpose of this study was to investigate whether persimmon tannin is associated with cholesterol efflux and macrophage-reverse cholesterol transport (RCT). In J774A.1 macrophage cells, persimmon tannin could inhibit cellular cholesterol accumulation and promote… read more here.
Keywords: reverse cholesterol; persimmon tannin; cholesterol; macrophage reverse ... See more keywords
The effects of subacute inhaled multi-walled carbon nanotube exposure on signaling pathways associated with cholesterol transport and inflammatory markers in the vasculature of wild-type mice.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.08.004
Abstract: Exposure to multi-walled carbon nanotubes (MWCNTs) has been associated with detrimental cardiovascular outcomes; however, underlying mechanisms have not yet been fully elucidated. Thus, we investigated alterations in proatherogenic and proinflammatory signaling pathways in C57Bl6/ mice… read more here.
Keywords: signaling pathways; cholesterol transport; walled carbon; exposure ... See more keywords
All-Atom Molecular Dynamics Simulations of Polyethylene Glycol (PEG) and LIMP-2 Reveal That PEG Penetrates Deep into the Proposed CD36 Cholesterol-Transport Tunnel
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00667
Abstract: Polyethylene glycol (PEG) is the most prominent clinically administered synthetic polymer. For example, over 300 million people have been administered PEGylated liposome vaccines for SARS-CoV-2. PEG is used in mammals because it has low affinity… read more here.
Keywords: peg; limp; cholesterol transport; polyethylene glycol ... See more keywords
A novel family of mammalian transmembrane proteins involved in cholesterol transport
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07077-z
Abstract: Cholesterol is an essential compound in mammalian cells because it is involved in a wide range of functions, including as a key component of membranes, precursor of important molecules such as hormones, bile acids and… read more here.
Keywords: sidt1 sidt2; novel family; transport; cholesterol ... See more keywords
Cholesterol Transport to the Endoplasmic Reticulum.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041263
Abstract: Most cholesterol in mammalian cells is stored in the plasma membrane (PM). Cholesterol transport from the PM to low-sterol regulatory regions of the endoplasmic reticulum (ER) controls cholesterol synthesis and uptake, and thereby influences the… read more here.
Keywords: transport endoplasmic; cholesterol; cholesterol transport; endoplasmic reticulum ... See more keywords