Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.01.023
Abstract: There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein,… read more here.
Keywords: rna oligonucleotides; chol oligorna; polyplex micelles; cholesteryl ... See more keywords
Hierarchical Gelation of a Pd12L24 Metal-Organic Cage Regulated by Cholesteryl Groups.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01171
Abstract: The creation of supramolecular assemblies by assembly of structurally simple components via supramolecular interactions provides an opportunity to develop functional materials with hierarchical complexibility. Herein, we report an assembly approach to supramolecular gels based on… read more here.
Keywords: gelation; cholesteryl groups; metal organic; cholesteryl ... See more keywords
Tissue Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/en.2019-00464
Abstract: ACSL4 is a member of the ACSL family that catalyzes the conversion of long chain fatty acids to acyl CoAs, which are essential for fatty acid incorporation and utilization into diverse metabolic pathways including cholesteryl… read more here.
Keywords: tissue specific; acsl4; cholesteryl ester; cholesteryl ... See more keywords
From Inert Storage to Biological Activity—In Search of Identity for Oxidized Cholesteryl Esters
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.602252
Abstract: Esterification of cholesterol is a universal mechanism to store and transport large quantities of cholesterol between organs and tissues and to avoid toxicity of the excess of cellular cholesterol. Intended for transport and storage and… read more here.
Keywords: biological activity; inert storage; storage biological; cholesteryl ... See more keywords
HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2025.1629496
Abstract: The potential impact of lifestyle changes such as prolonged fasting on brain health still remains unclear. Neurodegenerative diseases often exhibit two key hallmarks: accumulation of misfolded proteins such as amyloid beta oligomers (AβO) and intracellular… read more here.
Keywords: hdl; hdl fasted; cholesteryl; microglia hdl ... See more keywords
Tuning the Liquid Crystallinity of Cholesteryl-o-Carborane Dyads: Synthesis, Structure, Photoluminescence, and Mesomorphic Properties
Sign Up to like & getrecommendations! Published in 2021 at "Crystals"
DOI: 10.3390/cryst11020133
Abstract: A set of mesomorphic materials in which the o-carborane cluster is covalently bonded to a cholesteryl benzoate moiety (mesogen group) through a suitably designed linker is described. The olefin cross-metathesis between appropriately functionalized styrenyl-o-carborane derivatives… read more here.
Keywords: carborane; cluster; cholesteryl; liquid crystallinity ... See more keywords