The cation-π interaction in cysteine-rich domain of Smoothened is critical for its cholesterylation and function
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DOI: 10.3724/abbs.2022090
Abstract: The Hedgehog (Hh) signaling pathway is critical for embryonic development and tissue renewal. The G protein-coupled receptor (GPCR)-like protein Smoothened (SMO) is the central signal transducer in the Hh pathway. Cholesterol binds and then covalently… read more here.
Keywords: cysteine rich; rich domain; cholesterylation; cation interaction ... See more keywords