Amphiphilic xylan–cholic acid conjugates: synthesis and self-assembly behaviors in aqueous solution
Sign Up to like & getrecommendations! Published in 2017 at "Cellulose"
DOI: 10.1007/s10570-017-1595-0
Abstract: A novel amphiphilic biopolymer was synthesized by incorporating hydrophobic segment cholic acid (CA) into hydrophilic segment carboxymethyl xylan (CX) through coupling agent. Structural characteristics and self-assembly behaviors of the amphiphilic conjugates in aqueous solution were… read more here.
Keywords: xylan; self assembly; cholic acid; assembly behaviors ... See more keywords
Discovery of novel cholic acid derivatives as highly potent agonists for G protein-coupled bile acid receptor.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105588
Abstract: In this study, fourteen new cholic acid (CA) derivatives were designed and synthesized, and the GloSensor cAMP accumulation assay indicated that all derivatives could activate the Takeda G protein-coupled receptor 5 (TGR5). Methylation of 7-… read more here.
Keywords: cholic acid; acid; protein coupled; highly potent ... See more keywords
Surface plasma enhanced fluorescence combined aptamer sensor based on silica modified silver nanoparticles for signal amplification detection of cholic acid
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106524
Abstract: Abstract Cholic acid (CA), as an important gut bacterial metabolite in humans, would cause DNA damage when its level increases. Determination of CA is extremely significant and necessary in human because of its importance in… read more here.
Keywords: aptamer; signal amplification; surface; enhanced fluorescence ... See more keywords
Modulating Insulin Aggregation with Charge Variable Cholic Acid-Derived Polymers.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01107
Abstract: To understand the effect of cholic acid (CA)-based charge variable polymeric architectures on modulating the insulin aggregation process, herein, we have designed side-chain cholate-containing charge variable polymers. Three different types of copolymers from 2-(methacryloyloxy)ethyl cholate… read more here.
Keywords: aggregation; insulin aggregation; cholic acid; process ... See more keywords
Glycopolymeric Photosensitizers with Cholic Acid for HepG2-Targeted Chemo-Photodynamic Synergistic Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00165
Abstract: The aggregation-caused quenching, premature drug release, and hypoxia-caused resistance of photodynamic therapy (PDT) are challenges in the design and preparation of novel porphyrin-containing photosensitizers. In this work, a series of block copolymers consisting of a… read more here.
Keywords: synergistic therapy; cholic acid; therapy; photosensitizers cholic ... See more keywords
Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01293
Abstract: Emergence of vancomycin resistance in Gram-positive bacteria and the prevalence of vancomycin-resistant Enterococci (VRE) infections are highly alarming as very limited antibiotic options are available against VRE infections. Here, we present the synthesis of cholic… read more here.
Keywords: cholic acid; resistance; vancomycin; vre infections ... See more keywords
Deciphering the Role of Intramolecular Networking in Cholic Acid-Peptide Conjugates on the Lipopolysaccharide Surface in Combating Gram-Negative Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01357
Abstract: The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid-peptide conjugates (CAPs), demonstrating that valine-glycine dipeptide-derived… read more here.
Keywords: peptide conjugates; gram negative; acid peptide; cholic acid ... See more keywords
mPEG-Cholic acid/TPGS mixed micelles for combined delivery of paclitaxel and bufalin to treat hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical development and technology"
DOI: 10.1080/10837450.2022.2037140
Abstract: In this study, amphiphilic block copolymer mPEG-cholic acid was synthesized in conjunction with TPGS as stabilizer to prepare multifunctional micelles. The formed polymeric micelles (PCTm) were used for the delivery of paclitaxel (PTX) and bufalin… read more here.
Keywords: cholic acid; mpeg cholic; pctm; delivery paclitaxel ... See more keywords
A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00449-23
Abstract: Bacteria resistant to one or several antibiotics are a very large problem, threatening not only treatment of infections but also surgery and cancer treatments. Thus, new types of antibacterial drugs are desperately needed. ABSTRACT Listeria… read more here.
Keywords: ring fused; pyridone; cholic acid; listeria monocytogenes ... See more keywords
Anionic Technol PG-Based Nanoparticles Prepared Using Cholic Acid-Derived Surfactants
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Communications"
DOI: 10.1177/1934578x221098844
Abstract: In this work, the dispersibility of Technol PG, composed of anionic phospholipids, was investigated in the presence of cholic acid-based surfactants. read more here.
Keywords: anionic technol; cholic acid; based nanoparticles; acid ... See more keywords
Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes.
Sign Up to like & getrecommendations! Published in 2017 at "Nanomedicine"
DOI: 10.2217/nnm-2017-0361
Abstract: AIM To structurally modify our existing cholic acid (CA)-based telodendrimer (TD; PEG5K-CA8) for effective micellar nanoencapsulation and delivery of the US FDA-approved members of taxane family. MATERIALS & METHODS Generation of hybrid TDs was achieved… read more here.
Keywords: acid based; nanoplatform; cholic acid; approved taxanes ... See more keywords