Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline‐deficient l‐amino acid‐defined diet prevents hepatocarcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23516
Abstract: Hepatocellular carcinoma (HCC) is one of the most worrying tumors worldwide today, and its epidemiology is on the rise. Traditional pharmacological approaches have shown unfavorable results and exhibited many side effects. Hence, there is a… read more here.
Keywords: lysophosphatidic acid; hepatocarcinogenesis; acid; deficient amino ... See more keywords
Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet
Sign Up to like & getrecommendations! Published in 2022 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-022-07489-6
Abstract: Postmenopausal estrogen decline increases the risk of developing nonalcoholic steatohepatitis (NASH), and it might accelerate progression to cirrhosis and hepatocellular carcinoma. This study aimed to investigate a novel therapy for postmenopausal women who are diagnosed… read more here.
Keywords: deficient high; nonalcoholic steatohepatitis; high fat; choline deficient ... See more keywords
Time‐course microarrays reveal early activation of the immune transcriptome in a choline‐deficient mouse model of liver injury
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.07.009
Abstract: Aims Choline‐deficient diet is extensively used as a model of nonalcoholic fatty liver disease (NAFLD). In this study, we explored genes in the liver for which the expression changed in response to the choline‐deficient (CD)… read more here.
Keywords: choline; choline deficient; time course; model ... See more keywords
Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions
Sign Up to like & getrecommendations! Published in 2019 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2019.33553.8012
Abstract: Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective. Allantoin is one of the principal… read more here.
Keywords: endoplasmic reticulum; choline deficient; methionine choline; reticulum stress ... See more keywords
Luteolin alleviates methionine–choline-deficient diet-induced non-alcoholic steatohepatitis by modulating host serum metabolome and gut microbiome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.936237
Abstract: Background and purpose Previous studies have indicated the protective effects of luteolin against non-alcoholic steatohepatitis (NASH), but the definite underlying mechanism still remains unclear. This study aimed to explore the metabolomic and metagenomic signatures of… read more here.
Keywords: gut; non alcoholic; alcoholic steatohepatitis; luteolin ... See more keywords