Crosstalk of FGFR1 signaling and choline metabolism promotes cell proliferation and survival in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33922
Abstract: The acquisition of ectopic type I fibroblast growth factor receptor (FGFR1) is a common feature of prostate cancer (PCa), the most frequently diagnostic cancer in men. However, how ectopic FGFR1 contributes to PCa progression is… read more here.
Keywords: metabolism; prostate cancer; fgfr1; choline metabolism ... See more keywords
YAP drives cell competition by activating choline metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.101
Abstract: Cell competition is a phenomenon that eliminates unfit cells from cell society, a function vital for maintaining cellular and organismal homeostasis. We previously showed that Madin-Darby canine kidney (MDCK) epithelial cells expressing the active form… read more here.
Keywords: yap dependent; cell competition; competition; choline metabolism ... See more keywords
Abstract 1680: The immune checkpoint metabolome and its relationship with choline metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-1680
Abstract: Introduction: Immune checkpoint inhibition has emerged as an exciting treatment option for several cancers. New insights into the role of immune checkpoints in cellular metabolism can be used to optimize their effectiveness in treatment. Programmed… read more here.
Keywords: immune checkpoint; chk; choline metabolism; checkpoint ... See more keywords
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1038927
Abstract: Background Colon adenocarcinoma (COAD) is a common digestive system malignancy with high mortality and poor prognosis. Accumulating evidence indicates that choline metabolism is closely related to tumorigenesis and development. However, the efficacy of choline metabolism-related… read more here.
Keywords: metabolism related; metabolism; related signature; choline metabolism ... See more keywords
Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11121969
Abstract: The cellular and molecular basis of choline uptake on PET imaging and MRS-visible choline-containing compounds is not well understood. Choline kinase alpha (ChoKα) is an enzyme that phosphorylates choline, an essential step in membrane synthesis.… read more here.
Keywords: choline; fmc pet; choline metabolism; spectroscopy ... See more keywords
ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma
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DOI: 10.3390/cancers14030835
Abstract: Simple Summary We found that low expression of ATP8B1 was associated with poor prognosis, and involved in the dysregulation of glutathione (GSH) synthesis and choline metabolism in lung squamous cell carcinoma (LUSC) samples of The… read more here.
Keywords: lusc; cell; atp8b1 knockdown; choline metabolism ... See more keywords