Synthesis and Hydration Behavior of a Hydrolysis-Resistant Quasi-Choline Phosphate Zwitterionic Polymer.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00120
Abstract: A hydrolysis-resistant polymer bearing new quasi-choline phosphate (quasi-CP) structures as side groups, poly(2-methacryloyloxyethyl choline methylphosphonate) (PMCPm), was designed and synthesized. Radical polymerization and sub-surface-initiated radical polymerization were used to prepare homo-polymer and polymer brush on… read more here.
Keywords: choline; choline phosphate; quasi choline; polymer ... See more keywords
Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00484
Abstract: Zwitterionic methacrylate polymers with either choline phosphate (CP) (poly(MCP)) or phosphorylcholine (PC) (poly(MPC)) side groups were analyzed to characterize the bound hydration water molecules as nonfreezing water (NFW), intermediate water (IW), or free water (FW).… read more here.
Keywords: hydration; hydration water; choline phosphate; water ... See more keywords
Dipole Orientation Matters: Longer-Circulating Choline Phosphate than Phosphocholine Liposomes for Enhanced Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b03160
Abstract: Zwitterionic phosphocholine (PC) liposomes are widely used in drug delivery because of their high biocompatibility and long blood circulation time. We herein report that by flipping the direction of the PC dipole, the resulting choline… read more here.
Keywords: circulation time; phosphocholine liposomes; choline phosphate;
Bioreducible Polymer Nanocarrier Based on Multivalent Choline Phosphate for Enhanced Cellular Uptake and Intracellular Delivery of Doxorubicin.
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DOI: 10.1021/acsami.7b03317
Abstract: Limited cellular uptake and inefficient intracellular drug release severely hamper the landscape of polymer drug nanocarriers in cancer chemotherapy. Herein, to address these urgent challenges in tumor treatment simultaneously, we integrated the multivalent choline phosphate… read more here.
Keywords: choline phosphate; delivery; polymer; multivalent choline ... See more keywords
Choline Phosphate-Grafted Nanozymes as Universal Extracellular Vesicle Probes for Bladder Cancer Detection.
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DOI: 10.1021/acsnano.4c00280
Abstract: Urinary extracellular vesicles (uEVs) are regarded as highly promising liquid-biopsy biomarkers for the early diagnosis and prognosis of bladder cancer (BC). However, detection of uEVs remains technically challenging owing to their huge heterogeneity and ultralow… read more here.
Keywords: detection; choline phosphate; phosphate grafted; bladder cancer ... See more keywords
Choline phosphate lipid as an intra-crosslinker in liposomes for drug and antibody delivery under guard.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr07103c
Abstract: Liposomes are used to deliver therapeutics in vivo because of their good biocompatibility, efficient delivery, and ability to protect the therapeutics from degradation. However, the instability of liposomes will cause the therapeutics to lose protection… read more here.
Keywords: delivery; phosphate lipid; choline phosphate; antibody ... See more keywords