Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24235
Abstract: The septohippocampal cholinergic neurotransmission has long been implicated in seizures, but little is known about the structural features of this projection system in epileptic brain. We evaluated the effects of experimental epilepsy on the areal… read more here.
Keywords: system; septohippocampal cholinergic; fiber; experimental epilepsy ... See more keywords
Precise spike timing dynamics of hippocampal place cell activity sensitive to cholinergic disruption
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22753
Abstract: New memory formation depends on both the hippocampus and modulatory effects of acetylcholine. The mechanism by which acetylcholine levels in the hippocampus enable new encoding remains poorly understood. Here, we tested the hypothesis that cholinergic… read more here.
Keywords: precise spike; timing dynamics; spike timing; dynamics hippocampal ... See more keywords
The striatal cholinergic system in l-dopa-induced dyskinesias
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1845-9
Abstract: Cholinergic signaling plays a key role in regulating striatal function. The principal source of acetylcholine in the striatum is the cholinergic interneurons which, although low in number, densely arborize to modulate striatal neurotransmission. This modulation… read more here.
Keywords: induced dyskinesias; dopa induced; cholinergic system; cholinergic ... See more keywords
Bovine Endometritis and the Inflammatory Peripheral Cholinergic System
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03157-0
Abstract: Endometritis is an inflammation of the endometrium associated with bacterial infection. The pathogenesis of endometritis in cows is still not completely understood. The combined analysis of the markers of inflammation and oxidative stress has contributed… read more here.
Keywords: endometritis; subclinical endometritis; system; clinical subclinical ... See more keywords
NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.07.053
Abstract: Summary The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1… read more here.
Keywords: memory; required embryonic; learning memory; embryonic septum ... See more keywords
Modulation of the extraneuronal cholinergic system on main innate response leukocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.01.008
Abstract: The expression of elements of the cholinergic system has been demonstrated in non-neuronal cells, such as immune cells, where acetylcholine modulates innate and adaptive responses. However, the study of the non-neuronal cholinergic system has focused… read more here.
Keywords: innate; system; modulation extraneuronal; extraneuronal cholinergic ... See more keywords
Psychological Stress, Lung Function and Exacerbation Risk in COPD: Is an Increase of Cholinergic Tone a Possible Link?
Sign Up to like & getrecommendations! Published in 2018 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2018.1459533
Abstract: ABSTRACT Summary at a glance: On the hypothesis that psychological distress might interfere with airway reactivity in patients suffering of mild to moderate COPD through a cholinergic-mediated-bronchial reflex. read more here.
Keywords: stress lung; copd; function exacerbation; cholinergic ... See more keywords
A second wind for the cholinergic system in Alzheimer’s therapy
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000300
Abstract: Notwithstanding tremendous research efforts, the cause of Alzheimer’s disease (AD) remains elusive and there is no curative treatment. The cholinergic hypothesis presented 35 years ago was the first major evidence-based hypothesis on the etiology of… read more here.
Keywords: wind cholinergic; system alzheimer; second wind; cholinergic system ... See more keywords
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15553
Abstract: The prevention of tau protein aggregations is a therapeutic goal for the treatment of Alzheimer's disease (AD), and hydromethylthionine (HMT) (also known as leucomethylthioninium‐mesylate [LMTM]), is a potent inhibitor of tau aggregation in vitro and… read more here.
Keywords: memantine; rivastigmine memantine; ach; hmt ... See more keywords
Widespread posttranscriptional regulation of cotransmission.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adg9836
Abstract: While neurotransmitter identity was once considered singular and immutable for mature neurons, it is now appreciated that one neuron can release multiple neuroactive substances (cotransmission) whose identities can even change over time. To explore the… read more here.
Keywords: widespread posttranscriptional; cholinergic; posttranscriptional regulation; regulation cotransmission ... See more keywords
Cortical connectivity of cholinergic basal forebrain in Parkinson’s disease with mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2023 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-22-582
Abstract: Background Cholinergic basal forebrain (BF) pathology is a hallmark of Parkinson’s disease (PD) with mild cognitive impairment (PD-MCI). Assessment of functional connectivity (FC) of different cholinergic BF nuclei may deepen the understanding of PD-MCI pathogenesis.… read more here.
Keywords: cholinergic; group; cognitive impairment; seed ... See more keywords