Thalamic degeneration in MPTP-treated Parkinsonian monkeys: impact upon glutamatergic innervation of striatal cholinergic interneurons
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01967-w
Abstract: In both Parkinson’s disease (PD) patients and MPTP-treated non-human primates, there is a profound neuronal degeneration of the intralaminar centromedian/parafascicular (CM/Pf) thalamic complex. Although this thalamic pathology has long been established in PD (and other… read more here.
Keywords: degeneration; pathology; mptp treated; cholinergic interneurons ... See more keywords
Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson’s Disease Models
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2018.12.004
Abstract: The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs… read more here.
Keywords: disease; parkinson disease; indirect pathway; pfn ... See more keywords
Cholinergic Interneurons Provide a Link to Balance Excitation across Striatal Output Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.07.023
Abstract: D1-MSNs and D2-MSNs mediate output from the accumbens. How activity of one regulates the other is poorly understood. In this issue of Neuron, Francis et al. (2019) show that D1-MSN firing induces D2-MSN LTP via the… read more here.
Keywords: link balance; interneurons provide; provide link; output ... See more keywords
Substance P and dopamine interact to modulate the distribution of delta‐opioid receptors on cholinergic interneurons in the striatum
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13750
Abstract: It has been recently demonstrated that predictive learning induces a persistent accumulation of delta‐opioid receptors (DOPrs) at the somatic membrane of cholinergic interneurons (CINs) in the nucleus accumbens shell (Nac‐S). This accumulation is required for… read more here.
Keywords: dopr translocation; translocation; opioid receptors; cholinergic interneurons ... See more keywords
What’s wrong with the striatal cholinergic interneurons in Parkinson’s disease? Focus on intrinsic excitability
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14742
Abstract: Parkinson's disease (PD) is characterized by a degeneration of nigrostriatal dopaminergic neurons that results in a hypercholinergic state in the striatum. This hypercholinergic state contributes to the clinical signs of PD. However, the mechanisms that… read more here.
Keywords: hypercholinergic state; excitability; parkinson disease; wrong striatal ... See more keywords
Pyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abh4315
Abstract: Corticostriatal connectivity is central for many cognitive and motor processes, such as reinforcement or action initiation and invigoration. The cortical input to the striatum arises from two main cortical populations: intratelencephalic (IT) and pyramidal tract… read more here.
Keywords: excitatory inputs; tract neurons; excitatory; pyramidal tract ... See more keywords
17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.993552
Abstract: The striatum is an essential component of the basal ganglia that is involved in motor control, action selection and motor learning. The pathophysiological changes of the striatum are present in several neurological and psychiatric disorder… read more here.
Keywords: cholinergic neurons; adult mice; striatal cholinergic; effect ... See more keywords
Gap Junctions Between Striatal D1 Neurons and Cholinergic Interneurons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.674399
Abstract: The striatum participates in numerous important behaviors. Its principal projection neurons use GABA and peptides as neurotransmitters and interact extensively with interneurons, including cholinergic interneurons (ChIs) that are tonically active. Dissecting the interactions between projection… read more here.
Keywords: gap; neurons chis; gap junctions; projection neurons ... See more keywords
Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.945816
Abstract: Parkinson’s disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modulatory… read more here.
Keywords: synaptic inputs; dopamine depleted; striatal cins; activity ... See more keywords
Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.54170
Abstract: Spinal motor networks are formed by diverse populations of interneurons that set the strength and rhythmicity of behaviors such as locomotion. A small cluster of cholinergic interneurons, expressing the transcription factor Pitx2, modulates the intensity… read more here.
Keywords: synaptic mechanisms; mechanisms underlying; cholinergic interneurons; output ... See more keywords