Vocal learning in songbirds requires cholinergic signaling in a motor cortex-like nucleus.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurophysiology"
DOI: 10.1152/jn.00078.2018
Abstract: Cholinergic inputs to cortex modulate plasticity and sensory processing, yet little is known about their role in motor control. Here, we show that cholinergic signaling in a songbird vocal motor cortical area, the robust nucleus… read more here.
Keywords: cortical area; motor cortical; signaling motor; motor ... See more keywords
Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-2689
Abstract: These findings provide a promising therapeutic strategy to modulate the immunosuppressive microenvironment of pancreatic ductal adenocarcinoma with severe perineural invasion. Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the… read more here.
Keywords: invasion; pancreatic ductal; ductal adenocarcinoma; cholinergic signaling ... See more keywords
Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-0046
Abstract: In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been… read more here.
Keywords: tumorigenesis; directly indirectly; muscarinic receptors; indirectly suppresses ... See more keywords
Cholinergic Signaling Attenuates Pro-Inflammatory Interleukin-8 Response in Colonic Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.781147
Abstract: Infants affected by Hirschsprung disease (HSCR), a neurodevelopmental congenital disorder, lack ganglia of the intrinsic enteric nervous system (aganglionosis) in a variable length of the colon, and are prone to developing severe Hirschsprung-associated enterocolitis (HAEC).… read more here.
Keywords: response; hscr patients; rectosigmoid; pro inflammatory ... See more keywords
Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.635837
Abstract: Sensory perception underlies how we internalize and interact with the external world. In order to adapt to changing circumstances and interpret signals in a variety of contexts, sensation needs to be reliable, but perception of… read more here.
Keywords: cholinergic tone; basal; reward seeking; basal forebrain ... See more keywords
Role of Cholinergic Signaling in Alzheimer’s Disease
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DOI: 10.3390/molecules27061816
Abstract: Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline… read more here.
Keywords: role cholinergic; cholinergic; alzheimer disease; cholinergic signaling ... See more keywords
Muscarinic cholinergic signaling and overactive bladder-like symptoms associated with invasive bladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8715
Abstract: The objective of the present study was to explore the association between muscarinic cholinergic signaling and urothelial bladder tumors. Possible associations among overactive bladder (OAB) symptoms and bladder tumors were retrospectively investigated using a multicenter… read more here.
Keywords: bladder cancer; invasive bladder; bladder; cancer ... See more keywords