Cholinergic system changes of falls and freezing of gait in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25430
Abstract: Postural instability and gait difficulties (PIGDs) represent debilitating disturbances in Parkinson's disease (PD). Past acetylcholinesterase positron emission tomography (PET) imaging studies implicate cholinergic changes as significant contributors to PIGD features. These studies were limited in… read more here.
Keywords: freezing gait; system changes; gait; cholinergic system ... See more keywords
A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2020_141
Abstract: Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh) has proven to play an essential role in supporting many diverse functions. Some well-characterized functions include: chemical transmission at the neuromuscular junction; autonomic… read more here.
Keywords: system; review cholinergic; system therapeutic; brain disorders ... See more keywords
Neural Circuits for Sleep-Wake Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-7086-5_8
Abstract: The neural mechanisms of sleep, a fundamental biological behavior from invertebrates to humans, have been a long-standing mystery and present an enormous challenge. Gradually, perspectives on the neurobiology of sleep have been more various with… read more here.
Keywords: sleep wake; circuits sleep; rem sleep; cholinergic system ... See more keywords
The striatal cholinergic system in l-dopa-induced dyskinesias
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1845-9
Abstract: Cholinergic signaling plays a key role in regulating striatal function. The principal source of acetylcholine in the striatum is the cholinergic interneurons which, although low in number, densely arborize to modulate striatal neurotransmission. This modulation… read more here.
Keywords: induced dyskinesias; dopa induced; cholinergic system; cholinergic ... See more keywords
Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-017-9750-4
Abstract: Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid,… read more here.
Keywords: system; cardiac cholinergic; neuronal cardiac; cardiac ... See more keywords
Modulation of the extraneuronal cholinergic system on main innate response leukocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.01.008
Abstract: The expression of elements of the cholinergic system has been demonstrated in non-neuronal cells, such as immune cells, where acetylcholine modulates innate and adaptive responses. However, the study of the non-neuronal cholinergic system has focused… read more here.
Keywords: innate; system; modulation extraneuronal; extraneuronal cholinergic ... See more keywords
Parallel Atrophy of Cortex and Basal Forebrain Cholinergic System in Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw019
Abstract: Abstract The basal forebrain cholinergic system (BFCS) is the major source of acetylcholine for the cerebral cortex in humans. The aim was to analyze the pattern of BFCS and cortical atrophy in MCI patients to… read more here.
Keywords: cortex; parallel atrophy; basal forebrain; forebrain cholinergic ... See more keywords
A second wind for the cholinergic system in Alzheimer’s therapy
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000300
Abstract: Notwithstanding tremendous research efforts, the cause of Alzheimer’s disease (AD) remains elusive and there is no curative treatment. The cholinergic hypothesis presented 35 years ago was the first major evidence-based hypothesis on the etiology of… read more here.
Keywords: wind cholinergic; system alzheimer; second wind; cholinergic system ... See more keywords
Comparative study of the expression of cholinergic system components in the CNS of experimental autoimmune encephalomyelitis mice: Acute vs remitting phase
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14125
Abstract: Acetylcholine (ACh) is involved in the modulation of the inflammatory response. ACh levels are regulated by its synthesizing enzyme, choline acetyltransferase (ChAT), and by its hydrolyzing enzymes, mainly acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A more… read more here.
Keywords: system; acute remitting; expression; autoimmune encephalomyelitis ... See more keywords
Expression of components of the urothelial cholinergic system in bladder and cultivated primary urothelial cells of the pig
Sign Up to like & getrecommendations! Published in 2019 at "BMC Urology"
DOI: 10.1186/s12894-019-0495-z
Abstract: BackgroundPorcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce up to now. As it has… read more here.
Keywords: primary urothelial; cultivated primary; bladder; urothelial cells ... See more keywords
Characterization of social behavior in young and middle-aged ChAT-IRES-Cre mouse
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272141
Abstract: The cholinergic system is an important modulator of brain processes. It contributes to the regulation of several cognitive functions and emotional states, hence altering behaviors. Previous works showed that cholinergic (nicotinic) receptors of the prefrontal… read more here.
Keywords: cholinergic system; chat ires; ires cre; social behavior ... See more keywords