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Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800352
Abstract: A series of novel chroman‐4‐one derivatives were designed and synthesized successfully with good to excellent yield (3a–l). In addition, the obtained products were evaluated for their cholinesterase (ChE) inhibitory activities. The results show that among…
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Keywords:
design synthesis;
cholinesterase;
biological evaluation;
molecular dynamics ... See more keywords
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Published in 2020 at "Environmental research"
DOI: 10.1016/j.envres.2020.109539
Abstract: BACKGROUND In Chile organophosphate pesticides are widely used in the production of fruits. Pesticides use is regulated for professional practice but there is no regulation regarding exposure to the general population. OBJECTIVE To relate exposure…
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Keywords:
cholinesterase;
organophosphate;
inhibition;
exposure ... See more keywords
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Published in 2019 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.02.006
Abstract: Abstract Isoflavonoids and stilbenes were suggested as potential lead structures for inhibition of cholinesterases and in management of dementia. The Traditional Chinese (TCM) herb Belamcandae chinensis rhizoma (the rhizome of Iris domestica (L.) Goldblatt &…
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Keywords:
bche;
belamcandae chinensis;
chinensis rhizoma;
cholinesterase ... See more keywords
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Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c02471
Abstract: Cholinesterase enzymes are involved in a wide range of bodily functions, and their disruption is linked to pathologies such as neurodegenerative diseases and cancer. While cholinesterase inhibitors are used as drug treatments for diseases such…
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Keywords:
cholinesterase;
single walled;
cholinesterase enzymes;
activity ... See more keywords
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Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2017.1412314
Abstract: Abstract Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis,…
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Keywords:
cholinesterase;
cinnamic acid;
alzheimer disease;
acid hybrids ... See more keywords
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Published in 2023 at "Military medicine"
DOI: 10.1093/milmed/usad079
Abstract: The DoD Cholinesterase Monitoring Program and Cholinesterase Reference Laboratory have safeguarded U.S. government employees in chemical defense for over five decades. Considering Russia's potential deployment of chemical warfare nerve agents in Ukraine, it is critical…
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Keywords:
dod cholinesterase;
cholinesterase;
monitoring program;
cholinesterase monitoring ... See more keywords
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Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013714
Abstract: Rationale: Hereditary genetic mutations may cause congenital cholinesterase deficiency. When succinylcholine and mivacurium are applied on cholinesterase-deficient patients during general anesthesia, prolonged postoperative asphyxia occurs, which is an uncommon but very serious complication. Patient concerns:…
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Keywords:
cholinesterase;
congenital cholinesterase;
cholinesterase deficiency;
plasma cholinesterase ... See more keywords
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Published in 2017 at "Ibis"
DOI: 10.1111/ibi.12476
Abstract: The legal and illegal use of organophosphorus and carbamate pesticides represents one of many threats to birds. The activity of the cholinesterase enzyme in plasma is used as a non-destructive biomarker to diagnose the exposure…
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Keywords:
gyps fulvus;
cholinesterase;
cholinesterase activity;
plasma cholinesterase ... See more keywords
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Published in 2018 at "Occupational and Environmental Medicine"
DOI: 10.1136/oemed-2018-icohabstracts.1323
Abstract: Introduction The use of insecticides has been intensified in Brazilian agricultural production and control of endemic diseases. Plasma – or Butiryl -Cholinesterase (BCHE) is used for biological monitoring of organophosphates (OP) and carbamate exposure. Despite…
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Keywords:
cholinesterase;
term exposure;
long term;
exposure ... See more keywords
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Published in 2021 at "BMC Neurology"
DOI: 10.1186/s12883-021-02430-2
Abstract: Background Falls are a common complication of Parkinson’s disease. There is a need for new therapeutic options to target this debilitating aspect of the disease. Cholinergic deficit has been shown to contribute to both gait…
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Keywords:
trial;
cholinesterase;
falls parkinson;
disease ... See more keywords
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Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000207225
Abstract: Cholinesterase inhibitors such as galantamine and donepezil are among the few medications available that may slow the signs of dementia. However, their effects are modest, and the side effect profile may preclude their use in…
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Keywords:
effect;
cholinesterase;
cholinesterase inhibitors;
systematic review ... See more keywords