Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200142
Abstract: Alzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the involvement of an array of different… read more here.
Keywords: inhibition; toward cholinesterase; taddol derivatives; cholinesterase inhibition ... See more keywords
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01003
Abstract: Drug development efforts that focused on single targets failed to provide effective treatment for Alzheimer's disease (AD). Therefore, we designed cholinesterase inhibition (ChEI)-based multi-target-directed ligands (MTDLs) to simultaneously target AD-related receptors. We built a library… read more here.
Keywords: alzheimer disease; based multi; cholinesterase inhibition; target directed ... See more keywords
Validation and kinetic of enzymatic method for the detection of organophosphate insecticides based on cholinesterase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2019.1669248
Abstract: Abstract Kinetic and validation of the enzymatic method for the determination of fenitrothion organophosphorus based on cholinesterase inhibition were studied. A Linear relationship was obtained with a determination coefficient R2 of 0.9989 suggesting that the… read more here.
Keywords: cholinesterase inhibition; enzymatic method; detection; inhibition ... See more keywords