Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse
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DOI: 10.1007/s00213-017-4664-z
Abstract: AimIt is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase… read more here.
Keywords: allosteric modulator; nicotinic receptor; galantamine; effect ... See more keywords
Re‐pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population
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DOI: 10.1111/ajd.13356
Abstract: Eighty consecutive Chinese patients diagnosed with Alzheimer disease were assessed for darkening of grey hair. Of the 62 eligible patients (mean age = 79.3 ± 7.9 years; male: female = 1:1.48), 24/62 (38.7%, 95%CI: 26.6… read more here.
Keywords: cholinesterase inhibitor; hair; hair darkening; pigmentation hair ... See more keywords
Initial Cholinesterase Inhibitor Therapy Dose and Serious Events in Older Women and Men
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DOI: 10.1111/jgs.15442
Abstract: To examine dose‐related prescribing and short‐term serious events associated with initiation of cholinesterase inhibitor (ChEI) therapy. read more here.
Keywords: therapy; initial cholinesterase; cholinesterase inhibitor; serious events ... See more keywords
Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects.
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DOI: 10.2174/1567205015666171212105412
Abstract: BACKGROUND 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential, even better than parent compound tacrine, in vitro. Despite tacrine scaffold is broadly used for design and synthesis of novel compounds with anti-Alzheimer's potential, no… read more here.
Keywords: biochemistry; behavioural effects; chlorotacrine; compound ... See more keywords