Association of Concomitant Use of Cholinesterase Inhibitors or Memantine With Cognitive Decline in Alzheimer Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2018.4080
Abstract: Key Points Question Are cholinesterase inhibitors or memantine associated with cognitive outcomes in clinical trials for Alzheimer disease? Findings In this meta-analysis, participants receiving cholinesterase inhibitors or memantine had 1.4 points per year difference on… read more here.
Keywords: use cholinesterase; clinical trials; inhibitors memantine; association concomitant ... See more keywords
Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.08.003
Abstract: Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative disorders through restoration of acetylcholine (ACh) levels in the brain… read more here.
Keywords: quinoline containing; containing chalcone; chalcone derivatives; inhibitors silico ... See more keywords
The development of a butyrylcholinesterase porous pellet for innovative detection of cholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.09.015
Abstract: &NA; The aim of the presented research was the preparation of an innovative carrier with significantly improved properties for the fast and sensitive detection of cholinesterase inhibitors such as nerve agents. This innovative carrier was… read more here.
Keywords: cholinesterase inhibitors; butyrylcholinesterase; detection cholinesterase; activity ... See more keywords
Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.05.033
Abstract: Cholinergic projections have been shown to interact with estrogens in ways that influence synaptic plasticity and cognitive performance. The mechanisms are not well understood. The goal of this study was to investigate whether cholinergic projections… read more here.
Keywords: estrogen receptor; receptor expression; expression; cholinergic lesions ... See more keywords
Para-Substituted Thiosemicarbazones as Cholinesterase Inhibitors: Synthesis, In Vitro Biological Evaluation, and In Silico Study
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08108
Abstract: The current research reports the synthesis of 14 para-substituted thiosemicarbazone derivatives in good to excellent yields using standard procedures. Initially, 4-ethoxybenzaldehyde (1) and 4-nitrobenzaldehyde (2) were refluxed with thiosemicarbazide in the presence of acetic acid… read more here.
Keywords: cholinesterase inhibitors; silico; thiosemicarbazones cholinesterase; para ... See more keywords
A palliative care perspective on deprescribing cholinesterase inhibitors in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2018.1490255
Abstract: The cornerstone of palliative care is to improve quality of life for individuals and their families facing life-threatening illness. Dementia is a progressive, life-threatening illness with no cure... read more here.
Keywords: deprescribing cholinesterase; perspective deprescribing; palliative care; care perspective ... See more keywords
Anticholinergic co‐prescribing in nursing home residents using cholinesterase inhibitors: Potential deprescribing cascade
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.18066
Abstract: Polypharmacy may result from inappropriate prescribing of medications to treat adverse drug reactions (ADRs), i.e., “prescribing cascade.” A potentially harmful prescribing cascade affecting those with severe dementia can result when anticholinergics are prescribed to manage… read more here.
Keywords: nursing home; cholinesterase inhibitors; cascade; deprescribing cascade ... See more keywords
1369 Is plasma cholinesterase a reliable biomarker in long-term exposure to cholinesterase inhibitors?
Sign Up to like & getrecommendations! Published in 2018 at "Occupational and Environmental Medicine"
DOI: 10.1136/oemed-2018-icohabstracts.1323
Abstract: Introduction The use of insecticides has been intensified in Brazilian agricultural production and control of endemic diseases. Plasma – or Butiryl -Cholinesterase (BCHE) is used for biological monitoring of organophosphates (OP) and carbamate exposure. Despite… read more here.
Keywords: cholinesterase; term exposure; long term; exposure ... See more keywords
Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201161
Abstract: Background and Objectives Cholinesterase inhibitors (ChEIs) have cardiovascular effects in addition to their neurologic activity and might alter mortality. We wanted to know whether treatment with ChEIs modifies mortality in patients with dementia. Methods We… read more here.
Keywords: quality; cholinesterase inhibitors; mortality; mortality patients ... See more keywords
Editors' Note: Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000207225
Abstract: Cholinesterase inhibitors such as galantamine and donepezil are among the few medications available that may slow the signs of dementia. However, their effects are modest, and the side effect profile may preclude their use in… read more here.
Keywords: effect; cholinesterase; cholinesterase inhibitors; systematic review ... See more keywords
Trends and disparities in the use of cholinesterase inhibitors to treat Alzheimer's disease dispensed by the Brazilian public health system - 2008 to 2014: a nation-wide analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Arquivos de neuro-psiquiatria"
DOI: 10.1590/0004-282x20180064
Abstract: OBJECTIVE In light of the high cost of dementia treatment, there is legislation authorizing free distribution of cholinesterase inhibitors to those suffering from Alzheimer's disease in Brazil. However, the existence of this free distribution does… read more here.
Keywords: alzheimer disease; cholinesterase inhibitors; brazilian public; distribution ... See more keywords