Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02566-9
Abstract: A series of hydroxy-, oximino-, lactame, arylidene, N-methylpiperazinyl amide, isoxazole, pyrimidine derivatives of dipterocarpol, quinopimaric, and dammarenolic acids were synthesized and evaluated for cholinesterase inhibitory activity and cytotoxicity. All of the compounds were weak inhibitors… read more here.
Keywords: inhibitory activity; cholinesterase inhibitory; activity cytotoxicity;
Cholinesterase inhibitory alkaloids from the rhizomes of Coptis chinensis.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.01.038
Abstract: Coptis chinensis has been used as a medicinal herb in traditional oriental medicine. In this study, chemical investigation of a water extract of C. chinensis identified two new quaternary protoberberines (1, 2), a new tricyclic… read more here.
Keywords: inhibitory alkaloids; inhibition; cholinesterase inhibitory; coptis chinensis ... See more keywords
Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00563
Abstract: Phenotype-based screening of a fungal extract library yielded an active sample from a Penicillium sp. isolate that impaired zebrafish motility. Bioassay-guided purification led to the identification of 14 meroterpenoids including six new metabolites, arisugacins L-Q… read more here.
Keywords: phenotype based; inhibitory arisugacins; penicillium isolate; cholinesterase inhibitory ... See more keywords
Acetyl-cholinesterase Inhibitory Activity of Methoxyflavones Isolated from Kaempferia parviflora
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DOI: 10.1177/1934578x1701200107
Abstract: MeOH extracts of Kaempferia parviflora Wall. ex. Baker, family Zingiberaceae, were consecutively partitioned with CHCl3, EtOAc, and n-BuOH. The CHCl3 fractions were diluted in distilled water with n-hexane–CH2Cl2 and three methoxyflavones were isolated from the… read more here.
Keywords: cholinesterase inhibitory; methoxyflavones isolated; acetyl cholinesterase; inhibitory activity ... See more keywords
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease
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DOI: 10.3390/molecules28010238
Abstract: The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a novel series of benzophenone… read more here.
Keywords: cholinesterase inhibitory; inhibitory potency; affinity; directed ligands ... See more keywords
Variability of Hordeum vulgare L. Cultivars in Yield, Antioxidant Potential, and Cholinesterase Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2020 at "Sustainability"
DOI: 10.3390/su12051938
Abstract: Barley ( Hordeum vulgare L.) is an annual plant cultivated in spring or autumn. Currently, over 70% of the cultivated barley grains are utilized for preparing fodder, while the rest is used for the production… read more here.
Keywords: cholinesterase; potential cholinesterase; cholinesterase inhibitory; antioxidant potential ... See more keywords