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Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07993
Abstract: Coumarin is a naturally occurring bioactive pharmacophore with wide occurrence among central nervous system (CNS)-active small molecules. 8-Acetylcoumarin, one of the natural coumarins, is a mild inhibitor of cholinesterases and β-secretase, which are vital targets…
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Keywords:
synthesis biological;
biological evaluation;
coumarin;
triazole hybrids ... See more keywords
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Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666201020151804
Abstract: BACKGROUND Alzheimer's disease (AD) is an irreversible and progressive neurodegeneration, with a multifactorial pathophysiology, including cholinergic deficit, amyloid plaques, neurofibrillary tangles, oxidative stress, and neurodegeneration. Despite the severity of the disease, the therapeutic arsenal is…
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Keywords:
acting inhibitors;
alzheimer disease;
chalcones acting;
review ... See more keywords