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   Articles with "chon 001" as a keyword



The anti-fibrotic agent nintedanib protects chondrocytes against tumor necrosis factor-ɑ (TNF-ɑ)-induced extracellular matrix degradation

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2036899

Abstract: ABSTRACT Osteoarthritis is an inflammatory disease of the musculoskeletal system characterized by damaged articular cartilage. Nintedanib is an oral triple kinase inhibitor with anti-fibrotic and anti-inflammatory properties. Thus, we hypothesized that nintedanib might exert a… read more here.

Keywords: tnf induced; tnf; 001 chondrocytes; fibrotic agent ... See more keywords
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LncRNA DNM3OS promotes proliferation and inhibits apoptosis through modulating IGF1 expression by sponging MiR-126 in CHON-001 cells

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recommendations! Published in 2019 at "Diagnostic Pathology"

DOI: 10.1186/s13000-019-0877-2

Abstract: BackgroundAs a degenerative disease, osteoarthritis (OA) greatly affects aged population. The human chondrocyte cell line CHON-001, derived from normal human articular cartilage, has been widely used in vitro in osteoarthritis models. In order to better… read more here.

Keywords: mir 126; chon 001; proliferation; expression ... See more keywords
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Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis

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recommendations! Published in 2022 at "Bosnian Journal of Basic Medical Sciences"

DOI: 10.17305/bjbms.2021.6668

Abstract: Circular RNAs have been shown to be significant regulators in osteoarthritis (OA), whereas the functional effect of circ_0020014 in OA remains unclear. Our goal was to try and understand the underlying regulatory mechanism of circ_0020014… read more here.

Keywords: mir 613; adamts5; circ 0020014; 001 cells ... See more keywords
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MicroRNA-186-5p downregulation inhibits osteoarthritis development by targeting MAPK1

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recommendations! Published in 2021 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2021.11892

Abstract: As a chronic degenerative joint disease, the characteristics of osteoarthritis (OA) are degeneration of articular cartilage, subchondral bone sclerosis and bone hyperplasia. It has been reported that microRNA (miR)-186-5p serves a key role in the… read more here.

Keywords: 001 cell; chon 001; mir 186; 001 cells ... See more keywords