Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF‐β/SMAD2/3 pathway
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.14862
Abstract: Chondrocyte differentiation is crucial for cartilage formation. However, the complex processes and mechanisms coordinating chondrocyte proliferation and differentiation remain incompletely understood. Here, we report a novel function of the adaptor protein Gulp1 in chondrocyte differentiation.… read more here.
Keywords: differentiation; smad2 pathway; tgf smad2; gulp1 ... See more keywords
Spheroid culture for chondrocytes triggers the initial stage of endochondral ossification
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28203
Abstract: Endochondral ossification is the process of bone formation derived from growing cartilage duringskeletal development. In previous studies, we provoked the osteocyte differentiation of osteoblast precursor cells under a three‐dimensional (3D) culture model. To recapitulate the… read more here.
Keywords: culture; stage endochondral; endochondral ossification; chondrocyte ... See more keywords
Novel insights into the effect of deer IGF‐1 on chondrocyte viability and IL‐1β‐induced inflammation response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23227
Abstract: Clinical treatment of Osteoarthritis (OA) remains a challenge due to the poor self‐regeneration ability of cartilage. Deer antler is the only cartilage tissue that can completely regenerate each year. Insulin‐like growth factor 1 (IGF‐1) is… read more here.
Keywords: deer; chondrocyte; inflammation response; igf ... See more keywords
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23414
Abstract: Osteoarthritis (OA) is a common degenerative joint disease. The pathological changes of chondrocytes involve oxidative stress, the pro‐inflammatory response, and pro‐apoptotic events. Galectin‐3 (Gal‐3) is a 35 kDa protein with a special chimeric structure. Gal‐3 participates… read more here.
Keywords: chondrocyte; tc28a2 human; human chondrocyte; oxidative stress ... See more keywords
Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1584
Abstract: Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage degradation. In the face of global trends of population aging, OA is expected to become the fourth most common disabling disease by 2020.… read more here.
Keywords: new regulatory; regulatory code; apoptosis autophagy; chondrocyte ... See more keywords
Understanding factors affecting human chondrocyte culturing: an experimental study
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Banking"
DOI: 10.1007/s10561-020-09847-y
Abstract: Over the years, surgical strategies have been developed in hope of full regeneration of the injured cartilage. In our study, we aimed to develop an optimized chondrocyte culture isolation technique as an active ingredient of… read more here.
Keywords: affecting human; study; factors affecting; chondrocyte ... See more keywords
The impact of a key nutraceutical complex on chondrocyte cells and matrix Gla protein expression
Sign Up to like & getrecommendations! Published in 2021 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2021.101930
Abstract: Abstract Osteoarthritis (OA) is the most common type of arthritis among adults, which is associated with cartilage breakdown. Chondrocytes are the only type of cell in articular cartilage that secrete extracellular matrix (ECM). Therefore, to… read more here.
Keywords: expression; chondrocyte cells; impact key; chondrocyte ... See more keywords
Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β: a mathematical model.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.11.024
Abstract: The differentiation of mesenchymal stem cells (MSCs) into chondrocytes (native cartilage cells), or chondrogenesis, is a key step in the tissue engineering of articular cartilage, where the motility and high proliferation rate of MSCs used… read more here.
Keywords: chondrogenesis; chondrocyte; model; mscs ... See more keywords
Comparison of botulinum toxin type A and Rho-inhibitor on ATDC5 chondrocyte
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Physical and Rehabilitation Medicine"
DOI: 10.1016/j.rehab.2018.05.978
Abstract: Introduction/Background Knee osteoarthritis (OA) has an incidence rate of 25% per year and its responses to treatment are variable. The analgesic effect of intra-articular injection of botulinum toxin type A (BTX-A) has been observed in… read more here.
Keywords: rho inhibitor; btx; chondrocyte; type ... See more keywords
Tracking chondrocyte-to-fibroblast transformation via changes in cell electrophysiology
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DOI: 10.1038/s41598-025-98958-1
Abstract: Cultured chondrocytes have potential for cartilage regeneration to treat degenerative diseases. However, when explanted chondrocytes are cultured in monolayer, they are known to dedifferentiate over time, adopting a more fibroblastic phenotype. This greatly impacts both… read more here.
Keywords: chondrocyte fibroblast; tracking chondrocyte; transformation via; conductivity ... See more keywords
Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials Science"
DOI: 10.1039/d3bm00035d
Abstract: Auricular reconstruction in children with microtia is one of the more complex procedures in plastic surgery. Obtaining sufficient native material to build an ear requires harvesting large fragments of rib cartilage in children. Herein, we… read more here.
Keywords: autologous chondrocyte; ear; chondrocyte; cartilage ... See more keywords