Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy133
Abstract: Growth retardation is a constant feature of Noonan syndrome (NS) but its physiopathology remains poorly understood. We previously reported that hyperactive NS-causing SHP2 mutants impair the systemic production of insulin-like growth factor 1 (IGF1) through… read more here.
Keywords: shp2 mutants; mutants impair; chondrocyte differentiation; causing shp2 ... See more keywords
Precocious chondrocyte differentiation disrupts skeletal growth in Kabuki Syndrome mice.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.129380
Abstract: Kabuki syndrome 1 (KS1) is a Mendelian disorder of the epigenetic machinery caused by mutations in the gene encoding KMT2D, which methylates lysine 4 on histone H3 (H3K4). KS1 is characterized by intellectual disability, postnatal… read more here.
Keywords: chondrocyte differentiation; kabuki syndrome; precocious chondrocyte; chondrocyte ... See more keywords
Hydrostatic pressure prevents chondrocyte differentiation through heterochromatin remodeling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.247643
Abstract: Articular cartilage protects and lubricates joints for smooth motion and transmission of loads. Due to its high water content, chondrocytes within the cartilage are exposed to high levels of hydrostatic pressure, which has been shown… read more here.
Keywords: heterochromatin; chondrocyte differentiation; prevents chondrocyte; pressure prevents ... See more keywords
Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0218399
Abstract: Aggrecan is an integral component of the extracellular matrix in cartilaginous tissues, including the growth plate. Heterozygous defects in the aggrecan gene have been identified as a cause of autosomal dominant short stature, bone age… read more here.
Keywords: atdc5 cells; chondrocyte differentiation; chondrogenesis; required chondrocyte ... See more keywords
A Na+/K+ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.708384
Abstract: The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Here, we… read more here.
Keywords: length; chondrocyte differentiation; atpase pump; bone length ... See more keywords
Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.876825
Abstract: To explain how cartilage appeared in different parts of the vertebrate body at discrete times during evolution, we hypothesize that different embryonic populations co-opted expression of a core gene regulatory network (GRN) driving chondrocyte differentiation.… read more here.
Keywords: differentiation; chondrocyte; chondrocyte differentiation; limb head ... See more keywords
Integrated Analysis of Transcriptome Expression Profiles Reveals miRNA-326–NKX3.2-Regulated Porcine Chondrocyte Differentiation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087257
Abstract: The porcine body length trait is an essential factor affecting meat production and reproductive performance. It is evident that the development/lengthening of individual vertebrae is one of the main reasons for increases in body length;… read more here.
Keywords: development; analysis; porcine; chondrocyte differentiation ... See more keywords
MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11296
Abstract: Indian hedgehog signaling molecule (Ihh) is known to play critical roles in chondrogenesis and cartilage development. However, it remains largely unknown how Ihh is regulated during the process. Previous studies suggest that Ihh plays an… read more here.
Keywords: ihh; chondrocyte differentiation; expression; ihh expression ... See more keywords
Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish.
Sign Up to like & getrecommendations! Published in 2023 at "BMB reports"
DOI: 10.5483/bmbrep.2023-0056
Abstract: Elongation of most bones occur at the growth plate through endochondral ossification in postnatal mammals. The maturation of chondrocyte is a crucial factor in longitudinal bone growth, which is regulated by a complex network of… read more here.
Keywords: growth; chondrocyte differentiation; expression; sulfuretin ... See more keywords
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.37673
Abstract: The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases. However, the molecular mechanism(s) whereby the ISR impacts on differentiation is incompletely… read more here.
Keywords: chondrocyte differentiation; integrated stress; stress; differentiation ... See more keywords
NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.81569
Abstract: The origin and differentiation mechanism of articular chondrocytes remain poorly understood. Broadly, the difference in developmental mechanisms of articular and growth-plate cartilage is still less elucidated. Here, we identified that the nuclear factor of activated… read more here.
Keywords: cartilage; chondrocyte differentiation; differentiation; cartilage progenitors ... See more keywords