Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc
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DOI: 10.1038/s41420-018-0136-4
Abstract: Unexpectedly, we found that c-Myc-expressing porcine embryonic fibroblasts (PEFs) subcutaneously implanted into nude mice formed cartilage-like tissues in vivo, while previous studies revealed the direct conversion of mouse and human somatic cells into chondrocytes by… read more here.
Keywords: pig; chondrocyte like; like cells; direct conversion ... See more keywords
Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells
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DOI: 10.1371/journal.pone.0198079
Abstract: A human induced pluripotent stem cell line (GPCCi001-A) created by our group was differentiated towards chondrocyte-like cells (ChiPS) via monolayer culturing with growth factors. ChiPS are promising because they have the potential to be used… read more here.
Keywords: dna damage; chondrocyte like; like cells; differentiation ... See more keywords
Expression of Pluripotency Genes in Chondrocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells
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DOI: 10.3390/ijms19020550
Abstract: Human induced pluripotent stem cells (hiPSCs) constitute an important breakthrough in regenerative medicine, particularly in orthopedics, where more effective treatments are urgently needed. Despite the promise of hiPSCs only limited data on in vitro chondrogenic… read more here.
Keywords: chondrocyte like; human induced; pluripotency; pluripotent stem ... See more keywords
Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection
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DOI: 10.3892/ijmm.2017.3177
Abstract: Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of the nuclear factor-κB (NF-κB) signaling pathway and anti-inflammatory activity in a wide variety of cells. In the present study, the… read more here.
Keywords: chondrocyte like; atdc5 cells; mouse model; like atdc5 ... See more keywords
Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.
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DOI: 10.3892/ijmm.2019.4290
Abstract: Osteoarthritis (OA) is a progressive and degenerative joint disorder that is highly prevalent worldwide and for which there is currently no effective medical therapy. Artesunate (ART), a natural compound used to treat malaria, possesses diverse… read more here.
Keywords: chondrocyte like; atdc5 cells; mouse model; like atdc5 ... See more keywords