Tetrahedral DNA Nanostructure: A Potential Promoter for Cartilage Tissue Regeneration via Regulating Chondrocyte Phenotype and Proliferation.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201602770
Abstract: Utilizing biomaterials to regulate the phenotype and proliferation of chondrocytes is a promising approach for effective cartilage tissue regeneration. Recently, a significant amount of effort has been invested into directing chondrocytes toward a desired location… read more here.
Keywords: tissue regeneration; proliferation; phenotype proliferation; cartilage tissue ... See more keywords
RhoA activation and nuclearization marks loss of chondrocyte phenotype in crosstalk with Wnt pathway
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.08.033
Abstract: Abstract De‐differentiation comprises a major drawback for the use of autologous chondrocytes in cartilage repair. Here, we investigate the role of RhoA and canonical Wnt signaling in chondrocyte phenotype. Chondrocyte de‐differentiation is accompanied by an… read more here.
Keywords: wnt signaling; canonical wnt; differentiation; chondrocyte phenotype ... See more keywords
BMP7 reduces the fibrocartilage chondrocyte phenotype
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DOI: 10.1038/s41598-021-99096-0
Abstract: The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being explored as a potential… read more here.
Keywords: bmp7; protein levels; activity; chondrocyte phenotype ... See more keywords
IL-6, IL-1β and TNF-α regulation of the chondrocyte phenotype: a possible mechanism of haemophilic cartilage destruction.
Sign Up to like & getrecommendations! Published in 2023 at "Hematology"
DOI: 10.1080/16078454.2023.2179867
Abstract: OBJECTIVE Proinflammatory cytokines are considered to be one of the key causes of haemophilic cartilage destruction by inducing chondrocyte apoptosis and extracellular matrix degradation. However, few studies have focused on how proinflammatory cytokines regulate the… read more here.
Keywords: cartilage destruction; tnf; haemophilic cartilage; cartilage ... See more keywords
Increasing UCP2 expression and decreasing NOX1/4 expression maintain chondrocyte phenotype by reducing reactive oxygen species production.
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DOI: 10.18632/oncotarget.18908
Abstract: The aim of this study is to demonstrate that improving the mitochondrial function can inhibite the loss of chondrocyte phenotype by regulating the expression of uncoupling protein 2(UCP2) and NADPH oxidase1/4(NOX1/4) to reduce the production… read more here.
Keywords: reactive oxygen; expression; oxygen species; chondrocyte phenotype ... See more keywords
Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063279
Abstract: Numerous studies have assembled a complex picture, in which extracellular stimuli and intracellular signaling pathways modulate the chondrocyte phenotype. Because many diseases are mechanobiology-related, this review asked to what extent phenotype regulators control chondrocyte function… read more here.
Keywords: cytoskeleton; signaling processes; expression; chondrocyte phenotype ... See more keywords