Runx3 regulates chondrocyte phenotype by controlling multiple genes involved in chondrocyte proliferation and differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05646-6
Abstract: Chondrocytes are the sole cell type present within cartilage, and play pivotal roles in controlling the formation and composition of health cartilage. Chondrocytes maintain cartilage homeostasis through proliferating, differentiating and synthesizing different types of extracellular… read more here.
Keywords: proliferation; differentiation; runx3; chondrocyte proliferation ... See more keywords
Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109659
Abstract: Fluorine is an essential trace element for human health. However, excessive fluoride intake causes skeletal fluorosis which affects cartilage development. Fluoride inhibited chondrocyte proliferation which is the initial and critical step of endochondral ossification, but… read more here.
Keywords: mtor signaling; proliferation; signaling pathway; mtor ... See more keywords
Effects of Siwu decoction on chondrocyte proliferation of growth plate in adolescent rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.01.048
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE According to traditional Korean medicine theory in which children's growth retardation is attributed to blood deficiency, Siwu decoction (SWD), a representative treatment for blood deficiency, was chosen as a sample. AIM OF THE… read more here.
Keywords: siwu decoction; growth plate; proliferation growth; chondrocyte proliferation ... See more keywords
Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220159120
Abstract: Significance Osteolectin promotes the maintenance of bone mass in adult mice, but there has not been genetic evidence that Osteolectin is functionally important in humans. In the current study, we identified a function for Osteolectin… read more here.
Keywords: growth plate; chondrocyte proliferation; plate chondrocyte; bone elongation ... See more keywords
Long non-coding ribonucleic acid AFAP1-AS1 promotes chondrocyte proliferation via the miR-512-3p/matrix metallopeptidase 13 (MMP-13) axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031390
Abstract: ABSTRACT Long-chain non-coding RNAs are reported to be involved in cartilage damage. However, less research on the role of actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) in osteoarthritis. To investigate AFAP1-AS1 function in osteoarthritis… read more here.
Keywords: afap1 as1; mir 512; chondrocyte proliferation; expression ... See more keywords
Effects of Bakuchiol on chondrocyte proliferation via the PI3K‐Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12666
Abstract: Cartilaginous tissue degradation occurs because of the lack of survival of chondrocytes. Here, we ascertained whether bakuchiol (BAK) has the capability of activating chondrocyte proliferation. read more here.
Keywords: proliferation via; via pi3k; proliferation; bakuchiol chondrocyte ... See more keywords
USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1835900
Abstract: The purpose of this research was to observe the functions and mechanisms of ubiquitin-specific peptidase 7 (USP7) on chondrocytes under tumor necrosis factor alpha- (TNF-α-) induced inflammation. Knee osteoarthritis (OA) models of mice were constructed… read more here.
Keywords: inflammatory response; chondrocyte proliferation; inflammation; apoptosis inflammatory ... See more keywords
Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21082682
Abstract: Runx2 is required for chondrocyte proliferation and maturation. In the search of Runx2 target genes in chondrocytes, we found that Runx2 up-regulated the expression of hematopoietic cell kinase (Hck), which is a member of the… read more here.
Keywords: runx2; expression; hck; chondrocyte proliferation ... See more keywords
Whole-Transcriptome Sequencing of Antler Tissue Reveals That circRNA2829 Regulates Chondrocyte Proliferation and Differentiation via the miR-4286-R+1/FOXO4 Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087204
Abstract: The antler is the unique mammalian organ found to be able to regenerate completely and periodically after loss, and the continuous proliferation and differentiation of mesenchymal cells and chondrocytes together complete the regeneration of the… read more here.
Keywords: regeneration; antler; proliferation; chondrocyte proliferation ... See more keywords
Chondrocyte proliferation is promoted by 7-H-pyrrolo[2,3- d]pyrimidine via up-regulation of type II collagen matrix
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v19i4.2
Abstract: Purpose: To investigate the effect of 7-H-pyrrolo[2,3-d]pyrimidine derivative (7-HPPD) on the viability of chondrocytes in vitro, and to elucidate the associated mechanisms.Methods: Chondrocyte proliferation was determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay while cell cycle was… read more here.
Keywords: pyrrolo pyrimidine; proliferation; collagen matrix; chondrocyte proliferation ... See more keywords