Protective effect of vildagliptin on TNF‐α‐induced chondrocyte senescence
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DOI: 10.1002/iub.2049
Abstract: Osteoarthritis (OA) is a common age‐related disorder. Chondrocytes in joint tissue play a critical role in normal articular cartilage function and tissue homeostasis. Local inflammatory cytokine‐induced chondrocyte senescence contributes to the development and progression of… read more here.
Keywords: tnf induced; vildagliptin; senescence; induced chondrocyte ... See more keywords
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis.
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DOI: 10.1016/j.ijbiomac.2018.10.141
Abstract: The matrix metallopeptidase 13 (MMP13) is a central regulator of chondrocyte senescence that contributes to the development and progression of osteoarthritis (OA). In the present study, the native inhibitory structure of MMP13 in complex with… read more here.
Keywords: mmp13; site; inhibitory; mmp13 timp1 ... See more keywords
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
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DOI: 10.1136/annrheumdis-2021-221513
Abstract: Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Methods F-box and WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression and chondrocyte senescence… read more here.
Keywords: cartilage; osteoarthritis; fbxw7; mechanical overloading ... See more keywords
Response to: Correspondence on ‘Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7’ by Loeser et al
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DOI: 10.1136/annrheumdis-2022-222710
Abstract: In January 2022, we reported an important role for FBXW7 in the association between mechanical overloading, chondrocyte senescence and cartilage ageing in the pathology of osteoarthritis (OA). Our data support the idea that JNK signalling… read more here.
Keywords: mechanical overloading; chondrocyte senescence; jnk; correspondence ... See more keywords
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
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DOI: 10.3390/ijms23137043
Abstract: Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed… read more here.
Keywords: cell; gdf15; chondrocyte senescence; osteoarthritis ... See more keywords