Intensified Stiffness and Photodynamic Provocation in a Collagen‐Based Composite Hydrogel Drive Chondrogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201900099
Abstract: Abstract Directed differentiation of bone‐marrow‐derived stem cells (BMSCs) toward chondrogenesis has served as a predominant method for cartilage repair but suffers from poor oriented differentiation tendency and low differentiation efficiency. To overcome these two obstacles,… read more here.
Keywords: collagen; composite hydrogel; chondrogenesis; photodynamic provocation ... See more keywords
Synergistic effects of biological stimuli and flexion induce microcavities promote hypertrophy and inhibit chondrogenesis during in vitro culture of human mesenchymal stem cell aggregates
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400060
Abstract: Interzone/cavitation are key steps in early stage joint formation that have not been successfully developed in vitro. Further, current models of endochondral ossification, an important step in early bone formation, lack key morphology morphological structures… read more here.
Keywords: hypertrophy; early stage; chondrogenesis; culture ... See more keywords
Enhancement of Chondrogenesis by a Microcavitary Hydrogel Coculture System Synergizing With SDF‐1α and TGF‐Β3
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.70008
Abstract: A favorable microenvironment is of great significance for the repair of cartilage injury. In our previous study, a coculture system was devised, integrating genetically modified chondrocytes expressing transforming growth factor (TGF)‐β3 with ATDC5 cells, which… read more here.
Keywords: system; coculture system; chondrogenesis; microcavitary hydrogel ... See more keywords
miR‐182‐5p overexpression inhibits chondrogenesis by down‐regulating PTHLH
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11047
Abstract: Human bone marrow mesenchymal stem cells (hBM‐MSC) have the ability of differentiating into chondrocytes and osteoblasts. miR‐182‐5p promotes osteoclastogenesis and bone metastasis by up‐regulating the expression of parathyroid hormone‐like hormone (PTHLH). However, the function of… read more here.
Keywords: regulating pthlh; chondrogenesis; mir 182; 182 overexpression ... See more keywords
miR‐483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23552
Abstract: MicroRNAs (miRNAs) can regulate cellular differentiation processes by modulating multiple pathways simultaneously. Previous studies to analyze in vivo miRNA expression patterns in developing human limb cartilage tissue identified significant downregulation of miR‐483 in hypertrophic chondrocytes… read more here.
Keywords: chondrogenesis; differentiation; expression; mir 483 ... See more keywords
Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3440
Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium‐permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated… read more here.
Keywords: receptor potential; chondrogenesis; transient receptor; trpv4 ... See more keywords
Recombinant human type II collagen hydrogel provides a xeno‐free 3D micro‐environment for chondrogenesis of human bone marrow‐derived mesenchymal stromal cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.1983
Abstract: Recombinant human type II collagen (rhCII) hydrogel was tested as a xeno‐free micro‐environment for the chondrogenesis of human bone marrow‐derived mesenchymal stromal cells (BM‐MSCs). The rhCII hydrogels were seeded with BM‐MSCs and cultured in a… read more here.
Keywords: collagen; recombinant human; hydrogel; chondrogenesis ... See more keywords
Dynamics of Intrinsic Glucose Uptake Kinetics in Human Mesenchymal Stem Cells During Chondrogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-018-2067-x
Abstract: Chondrogenesis of human mesenchymal stem cells (hMSCs) is an important biological process in many applications including cartilage tissue engineering. We investigated the glucose uptake characteristics of aggregates of hMSCs undergoing chondrogenesis over a 3-week period… read more here.
Keywords: human mesenchymal; chondrogenesis; glucose uptake; day ... See more keywords
In Vivo Bioreactor Using Cellulose Membrane Benefit Engineering Cartilage by Improving the Chondrogenesis and Modulating the Immune Response
Sign Up to like & getrecommendations! Published in 2020 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-019-00236-5
Abstract: To regenerate tissue-engineered cartilage as a source of material for the restoration of cartilage defects, we used a human fetal cartilage progenitor cell pellet to improve chondrogenesis and modulation of the immune response in an… read more here.
Keywords: chondrogenesis; immune response; vivo bioreactor; cell ... See more keywords
Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.06.016
Abstract: Three-dimensional hydrogel constructs incorporated with live stem cells that support chondrogenic differentiation and maintenance offer a promising regenerative route towards addressing the limited self-repair capabilities of articular cartilage. In particular, hydrogel scaffolds that augment chondrogenesis… read more here.
Keywords: cell; chondrogenesis; material; stem cells ... See more keywords
Study on the effects of gradient mechanical pressures on the proliferation, apoptosis, chondrogenesis and hypertrophy of mandibular condylar chondrocytes in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2016.10.017
Abstract: OBJECTIVE To investigate the effects of gradient mechanical pressure on chondrocyte proliferation, apoptosis, and the expression of markers of chondrogenesis and chondrocyte hypertrophy. METHODS Mandibular condylar chondrocytes from 5 rabbits were cultured in vitro, and… read more here.
Keywords: apoptosis; proliferation apoptosis; chondrogenesis; hypertrophy ... See more keywords